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Found 51 with Last Name = 'tokar' and Initial = 'c'
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167611((2R,5R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167619((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167618((2R,5R)-1-[4-(4-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167620((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167621((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(3-methyl-benz...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167609((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167605((2R,5R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167617((2R,5R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  4.30nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167605((2R,5R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  5.20nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167620((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  6.20nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167608((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167610((2R,5R)-1-[4-(2-Ethyl-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  6.70nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167606((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(2-methyl-pyri...)
Affinity DataIC50:  6.70nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167608((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  7.30nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167613((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(2-methyl-benz...)
Affinity DataIC50:  7.30nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167607((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(quinolin-4-yl...)
Affinity DataIC50:  7.80nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167622((2R,5R)-1-[4-(2-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167618((2R,5R)-1-[4-(4-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167614((2R,5R)-5-Hydroxy-1-[4-(isoquinolin-1-ylmethoxy)-b...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167619((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167622((2R,5R)-1-[4-(2-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167612((2R,5R)-5-Hydroxy-1-[4-(2-isopropyl-benzyloxy)-ben...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167621((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(3-methyl-benz...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167623((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(3-methyl-isot...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167613((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(2-methyl-benz...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167624((2R,5R)-1-[4-(3-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167616((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-isot...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167617((2R,5R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167615((2R,5R)-1-[4-(3-Chloro-pyridin-4-ylmethoxy)-benzen...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50167609((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167610((2R,5R)-1-[4-(2-Ethyl-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  36nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167614((2R,5R)-5-Hydroxy-1-[4-(isoquinolin-1-ylmethoxy)-b...)
Affinity DataIC50:  53nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167618((2R,5R)-1-[4-(4-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167607((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(quinolin-4-yl...)
Affinity DataIC50:  170nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167612((2R,5R)-5-Hydroxy-1-[4-(2-isopropyl-benzyloxy)-ben...)
Affinity DataIC50:  188nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167619((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...)
Affinity DataIC50:  198nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167605((2R,5R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  255nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167614((2R,5R)-5-Hydroxy-1-[4-(isoquinolin-1-ylmethoxy)-b...)
Affinity DataIC50:  290nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167609((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...)
Affinity DataIC50:  430nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167611((2R,5R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  592nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167617((2R,5R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  679nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167613((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(2-methyl-benz...)
Affinity DataIC50:  690nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167622((2R,5R)-1-[4-(2-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  715nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167621((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(3-methyl-benz...)
Affinity DataIC50:  773nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167608((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  790nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167615((2R,5R)-1-[4-(3-Chloro-pyridin-4-ylmethoxy)-benzen...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167610((2R,5R)-1-[4-(2-Ethyl-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167612((2R,5R)-5-Hydroxy-1-[4-(2-isopropyl-benzyloxy)-ben...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167620((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50076476(1-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-cy...)
Affinity DataEC50:  4.90E+4nMAssay Description:Compound was tested for the stimulation of Phosphoinositide (PI) hydrolysis in BHK cells expresssing mGluR5a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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