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Found 270 with Last Name = 'wilm' and Initial = 'c'
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070888(CHEMBL298725 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  0.0320nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50069575(3-Benzo[1,2,5]thiadiazol-5-yl-5-hydroxy-5-(4-metho...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070884(CHEMBL48907 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  0.300nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of [125I]-ET-1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070886(CHEMBL51234 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  1nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50034263(CHEMBL25438 | PD-156707 | Sodium; (Z)-2-benzo[1,3]...)
Affinity DataIC50:  1.30nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070881(CHEMBL295483 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  1.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  1.5nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070882((Z)-2-Benzo[1,2,5]thiadiazol-5-yl-4-(2-fluoro-4-me...)
Affinity DataIC50:  3nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070877(CHEMBL262000 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  3.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070890(CHEMBL51890 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  3.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070871(CHEMBL431160 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  3.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50075421(7-(Ethyl-methanesulfonyl-amino)-1-(2-methoxy-benzy...)
Affinity DataIC50:  3.60nMAssay Description:Ability to displace [125I]-Endothelin-1 from endothelin B receptor in porcine kidney membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070873(CHEMBL301577 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  3.70nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070892(CHEMBL299572 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  4.60nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070876(CHEMBL299328 | Sodium; (Z)-4-benzo[1,3]dioxol-5-yl...)
Affinity DataIC50:  6.5nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50057155((Z)-2-Benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-...)
Affinity DataIC50:  7.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50075429(7-(Methanesulfonyl-methyl-amino)-1-(2-methoxy-benz...)
Affinity DataIC50:  8.60nMAssay Description:Ability to displace [125I]-Endothelin-1 from endothelin B receptor in porcine kidney membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034051(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  8.60nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(BOVINE)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  9nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor was determined using [ [3H]spiperone radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070891(CHEMBL48458 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  12nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50075422(7-(Methanesulfonyl-propyl-amino)-1-(2-methoxy-benz...)
Affinity DataIC50:  13nMAssay Description:Ability to displace [125I]-Endothelin-1 from endothelin B receptor in porcine kidney membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070879(CHEMBL299521 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  14nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070869(CHEMBL48411 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  16nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034032(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  16nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070889(CHEMBL51030 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  17nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290940(CHEMBL94929 | N-[2-Benzo[1,3]dioxol-5-yl-2-(3,5-di...)
Affinity DataIC50:  18nMAssay Description:Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290940(CHEMBL94929 | N-[2-Benzo[1,3]dioxol-5-yl-2-(3,5-di...)
Affinity DataIC50:  18nMAssay Description:Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  18nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290940(CHEMBL94929 | N-[2-Benzo[1,3]dioxol-5-yl-2-(3,5-di...)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50075412(1-(2,5-Dimethoxy-benzyl)-4-(4-methoxy-phenyl)-2-ox...)
Affinity DataIC50:  21nMAssay Description:Ability to displace [125I]-Endothelin-1 from endothelin A receptor in rat aorta membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50069569(5-Dimethylamino-naphthalene-1-sulfonic acid benzo[...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [125I]-ET-1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034041(1-(4-{4-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  23nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070878(CHEMBL48881 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  26nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50075435(7-Amino-1-(2-methoxy-benzyl)-4-(4-methoxy-phenyl)-...)
Affinity DataIC50:  27nMAssay Description:Ability to displace [125I]-Endothelin-1 from endothelin B receptor in porcine kidney membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070874(CHEMBL301971 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  28nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070868(CHEMBL49675 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  28nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290949(CHEMBL94918 | N-[2-Benzo[1,3]dioxol-5-yl-2-(3,5-di...)
Affinity DataIC50:  29nMAssay Description:Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290950(CHEMBL421563 | N-[2-Benzo[1,3]dioxol-5-yl-2-(3-met...)
Affinity DataIC50:  32nMAssay Description:Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290953(CHEMBL96762 | N-[2-Benzo[1,3]dioxol-5-yl-2-(5-ethy...)
Affinity DataIC50:  32nMAssay Description:Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50069571(3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...)
Affinity DataIC50:  33nMAssay Description:Inhibition of [125I]-ET-1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290952(CHEMBL330424 | N-[2-Benzo[1,3]dioxol-5-yl-2-(3-met...)
Affinity DataIC50:  34nMAssay Description:Compound was evaluated for the antagonism at the Endothelin B receptor in isolated rabbit jugularis veinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataIC50:  38nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034047(2-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50:  40nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50290954(4-[1-Benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenes...)
Affinity DataIC50:  41nMAssay Description:Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50075412(1-(2,5-Dimethoxy-benzyl)-4-(4-methoxy-phenyl)-2-ox...)
Affinity DataIC50:  41nMAssay Description:Ability to displace [125I]-Endothelin-1 from endothelin B receptor in porcine kidney membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034072(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  45nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070872(CHEMBL276362 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  57nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034071(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  58nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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