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Found 2052 with Last Name = 'murphy' and Initial = 'e'
Target5-hydroxytryptamine receptor 2B(RAT)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM82472(BW-723C86 | CAS_5311036 | NSC_5311036)
Affinity DataKi:  12.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004927(4-Phosphonomethyl-piperidine-2-carboxylic acid | 4...)
Affinity DataKi:  140nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002360((CPP)4-(3-Phosphono-propyl)-piperazine-2-carboxyli...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
LigandPNGBDBM50002360((CPP)4-(3-Phosphono-propyl)-piperazine-2-carboxyli...)
Affinity DataKi:  220nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM82472(BW-723C86 | CAS_5311036 | NSC_5311036)
Affinity DataKi:  316nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM81977(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Affinity DataKi:  350nMMore data for this Ligand-Target Pair
LigandPNGBDBM81977(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
LigandPNGBDBM31174(CHEMBL29757 | D-Aspartate | D-Aspartic Acid)
Affinity DataKi:  800nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31174(CHEMBL29757 | D-Aspartate | D-Aspartic Acid)
Affinity DataKi:  900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002363((APH)2-Amino-7-phosphono-heptanoic acid | 2-Amino-...)
Affinity DataKi:  900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002363((APH)2-Amino-7-phosphono-heptanoic acid | 2-Amino-...)
Affinity DataKi:  1.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKi:  1.40E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002343(2-Methylamino-succinic acid | CHEMBL275325 | NMDA)
Affinity DataKi:  4.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002343(2-Methylamino-succinic acid | CHEMBL275325 | NMDA)
Affinity DataKi:  5.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataKi:  8.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataKi:  8.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26116(CHEMBL284104 | Dipicolinate | pyridine carboxylate...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50554937(CHEMBL4780654 | US20240059655, Compound PW0787)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5-HT2C (unknown origin) assessed as inhibition of ligand bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | CAS_492-27-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26115(CHEMBL286204 | Quinolinate | Quinolinic acid | pyr...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM81976(CAS_16450-41-2 | L-GDEE | glutamic acid diethyl es...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | CAS_492-27-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26116(CHEMBL284104 | Dipicolinate | pyridine carboxylate...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM81976(CAS_16450-41-2 | L-GDEE | glutamic acid diethyl es...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26115(CHEMBL286204 | Quinolinate | Quinolinic acid | pyr...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
TargetPlacenta growth factor(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50339214(CHEMBL1689480)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mouse PlGF-VEGFR-1 interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239498(CHEMBL4093120 | US10329302, Example 189 | US107935...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541838(CHEMBL4649483)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlacenta growth factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50339212(CHEMBL1689483)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human PlGF-1-VEGFR-1 interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239507(CHEMBL4091434 | US10329302, Example 246 | US107935...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239508(CHEMBL4085199 | US10329302, Example 309 | US107935...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlacenta growth factor(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50339209(CHEMBL1689479)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of mouse PlGF-VEGFR-1 interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563108((3S)-N-[4-methyl-3-[2-(1-methylpyrazol- 3-yl)-6-(m...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563072(N-(2-hydroxyethyl)-N-methyl-4-[2- methyl-5-[(3S)-3...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563074(N,N-dimethyl-4-[2-methyl-5-[(3S)-3- (2,2,2-trifluo...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563076((3S)-N-[3-[2-(3-hydroxyazetidine-1- carbonyl)-6-(m...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563078((3S)-N-[3-[2-(3-hydroxy-3- methylazetidine-1-carbo...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563080((3S)-N-[4-methyl-3-[2-(l-methylpyrazol- 4-yl)-6-(m...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563081((2R)-N-{4-methyl-3-[2-(2- methylpyrazol-3-yl)-6-(m...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlacenta growth factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50339210(CHEMBL1689481)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PlGF-1-VEGFR-1 interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM563119((3R)-3-(1,1-difluoroethyl)-N-{2-fluoro-4- methyl-5...)
Affinity DataIC50: <1nMAssay Description:Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief, for each reaction, k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM559899(N-(3-{2-[(3S)-3-aminobut-1-yn-1-yl]-6- (morpholin-...)
Affinity DataIC50: <1nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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