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Found 81 with Last Name = 'kovacs' and Initial = 'ed'
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM28124(3-cyanoquinoline, 9 | 6-methoxy-7-[3-(morpholin-4-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099987(4-(4-Benzyl-phenylamino)-6-methoxy-7-(3-morpholin-...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099990(4-(4-Benzyl-phenylamino)-6,7-dimethoxy-quinoline-3...)
Affinity DataIC50:  3.60nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099983(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-thioph...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099981(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-thioph...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM28124(3-cyanoquinoline, 9 | 6-methoxy-7-[3-(morpholin-4-...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  6.20nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095235(6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-4-(4-phenoxy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099984(4-(4-Furan-3-ylmethyl-phenylamino)-6-methoxy-7-(3-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099987(4-(4-Benzyl-phenylamino)-6-methoxy-7-(3-morpholin-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099979(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-pyridi...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095236(6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099981(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-thioph...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099978(4-(4-Furan-2-ylmethyl-phenylamino)-6-methoxy-7-(3-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099985(4-(4-Cyclohexylsulfanyl-phenylamino)-6-methoxy-7-(...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099983(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-thioph...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095235(6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-4-(4-phenoxy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099988(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-[4-(pyrid...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095229(7-(3-Morpholin-4-yl-propoxy)-4-(4-phenoxy-phenylam...)
Affinity DataIC50:  28nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099976(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-pyridi...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099991(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenet...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Dual specificity mitogen-activated protein kinase kinase in coupled activated Raf/MEK assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095236(6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  35nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099990(4-(4-Benzyl-phenylamino)-6,7-dimethoxy-quinoline-3...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099984(4-(4-Furan-3-ylmethyl-phenylamino)-6-methoxy-7-(3-...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099982(4-[4-(4-Chloro-phenoxy)-phenylamino]-6,7-dimethoxy...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095230(5,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099978(4-(4-Furan-2-ylmethyl-phenylamino)-6-methoxy-7-(3-...)
Affinity DataIC50:  66nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095229(7-(3-Morpholin-4-yl-propoxy)-4-(4-phenoxy-phenylam...)
Affinity DataIC50:  68nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099979(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-pyridi...)
Affinity DataIC50:  72nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099988(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-[4-(pyrid...)
Affinity DataIC50:  81nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095234(7-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  95nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095231(5-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  98nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099989(6-Methoxy-4-(4-methoxy-phenylamino)-7-(3-morpholin...)
Affinity DataIC50:  99nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099976(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-pyridi...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099975(4-(4-Cyclohexyloxy-phenylamino)-6-methoxy-7-(3-mor...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095233(4-(4-Phenoxy-phenylamino)-quinoline-3-carbonitrile...)
Affinity DataIC50:  125nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095234(7-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  125nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099991(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenet...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099977(6,7-Dimethoxy-4-(4-phenylamino-phenylamino)-quinol...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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