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Found 39 with Last Name = 'schweighoffer' and Initial = 'f'
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM101038(US8524917, 11 | US8563594, 169)
Affinity DataIC50:  5nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM101039(US8524917, 12 | US8563594, 170)
Affinity DataIC50:  6nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103621(US8563594, 171)
Affinity DataIC50:  17nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM101037(US8524917, 10 | US8563594, 168)
Affinity DataIC50:  19nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103616(US8563594, 166)
Affinity DataIC50:  31nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103614(US8563594, 164)
Affinity DataIC50:  35nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103617(US8563594, 167)
Affinity DataIC50:  209nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103604(US8563594, 153)
Affinity DataIC50:  231nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM38239(US8563594, 154 | US8563594, Unnumbered 2)
Affinity DataIC50:  319nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM38239(US8563594, 154 | US8563594, Unnumbered 2)
Affinity DataIC50:  319nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103611(US8563594, 160)
Affinity DataIC50:  319nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103608(US8563594, 157)
Affinity DataIC50:  1.10E+3nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300554(((2S,3R,4S,5S)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103603(US8563594, 152)
Affinity DataIC50:  1.60E+3nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103609(US8563594, 158)
Affinity DataIC50:  1.80E+3nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103606(US8563594, 155)
Affinity DataIC50:  1.80E+3nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103613(US8563594, 162)
Affinity DataIC50:  1.90E+3nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300554(((2S,3R,4S,5S)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM103612(US8563594, 161)
Affinity DataIC50:  4.00E+3nMAssay Description:FLIPR assay using S1P3 receptor inhibitor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300547(2,3,9,10-Tetrahydroxy-5,6-dihydro-isoquino[3,2-a]i...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300547(2,3,9,10-Tetrahydroxy-5,6-dihydro-isoquino[3,2-a]i...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300551(2,3,7,8-Tetrahydroxy-5-methyl-benzo[c]phenanthridi...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300551(2,3,7,8-Tetrahydroxy-5-methyl-benzo[c]phenanthridi...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300548(3,4,10,11-Tetrahydroxy-8-methyl-isoquino[3,2-a]iso...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300545(CHEMBL573174 | tetrahydroxycanadine hydrochloride)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300548(3,4,10,11-Tetrahydroxy-8-methyl-isoquino[3,2-a]iso...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300552(2,3-Dihydroxy-7,8-dimethoxy-5-methyl-benzo[c]phena...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300546(6,7-Dimethoxy-1-methyl-3-naphthalen-2-yl-isoquinol...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300549(2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300552(2,3-Dihydroxy-7,8-dimethoxy-5-methyl-benzo[c]phena...)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300549(2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300550(3-(3,4-Dihydroxy-phenyl)-6,7-dimethoxy-1-methyl-is...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM25524(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM25524(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300545(CHEMBL573174 | tetrahydroxycanadine hydrochloride)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300546(6,7-Dimethoxy-1-methyl-3-naphthalen-2-yl-isoquinol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM50300550(3-(3,4-Dihydroxy-phenyl)-6,7-dimethoxy-1-methyl-is...)
Affinity DataIC50:  1.04E+5nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed