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Found 40 with Last Name = 'cseke' and Initial = 'g'
LigandPNGBDBM391716(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50539955(CHEMBL4638938)
Affinity DataKi:  0.0251nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
LigandPNGBDBM391723(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...)
Affinity DataKi:  0.0398nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391725(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391724(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391718(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50539954(CHEMBL4636143)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50318701(CHEMBL1083659 | MK-4305 | [(7R)-4-(5-Chloro-1,3-be...)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM154947(US9000029, 26)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50318701(CHEMBL1083659 | MK-4305 | [(7R)-4-(5-Chloro-1,3-be...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM334973(US11040966, Example 5.36 | US9732075, Example 5.36...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM334973(US11040966, Example 5.36 | US9732075, Example 5.36...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520181(CHEMBL2413522)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520182(CHEMBL3740099)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM154947(US9000029, 26)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520180(CHEMBL4590386)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520179(CHEMBL4592653)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50384416(CHEMBL2111553 | CHEMBL291536 | SB-334867)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50423648(CHEMBL1334465 | SB-408124)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520182(CHEMBL3740099)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520179(CHEMBL4592653)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520181(CHEMBL2413522)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520180(CHEMBL4590386)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50384416(CHEMBL2111553 | CHEMBL291536 | SB-334867)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50423648(CHEMBL1334465 | SB-408124)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50434481(CHEMBL2385132 | CHEMBL2385133 | CHEMBL2385134)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50434481(CHEMBL2385132 | CHEMBL2385133 | CHEMBL2385134)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at MRGPX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed