Affinity DataIC50: 0.360nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.680nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.690nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.850nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.850nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 0.890nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair