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Found 1465 with Last Name = 'mcalpine' and Initial = 'i'
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490791(9-((4S,6R,7S,11aR,13R,14R,14aR,15R)-13-(6-amino-9H...)
Affinity DataKi:  0.190nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490773(US10968242, Example 2 Peak 4)
Affinity DataKi:  0.200nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490777(US10968242, Example 3 Peak 4)
Affinity DataKi:  0.200nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490790(US10968242, Example 17 Peak 2)
Affinity DataKi:  0.300nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193709(CHEMBL3911017)
Affinity DataKi:  0.700nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex using HeLa cells der...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490787(US10968242, Example 16 Peak 1)
Affinity DataKi:  1nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490786(US10968242, Example 15 Peak 2)
Affinity DataKi:  1nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490776(US10968242, Example 3 Peak 3)
Affinity DataKi:  1nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490789(US10968242, Example 17 Peak 1)
Affinity DataKi:  2nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490794(US10968242, Example 19 Peak 3)
Affinity DataKi:  2nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490772(US10968242, Example 2 Peak 3)
Affinity DataKi:  2nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193663(CHEMBL3929944)
Affinity DataKi:  2nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex using HeLa cells der...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389112(CHEMBL2064556)
Affinity DataKi:  2.80nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490781(US10968242, Example 7 Peak 4)
Affinity DataKi:  3nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389111(CHEMBL2064555)
Affinity DataKi:  3.40nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490774(US10968242, Example 3 Peak 1)
Affinity DataKi:  4nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389111(CHEMBL2064555)
Affinity DataKi:  6nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490770(US10968242, Example 2 Peak 1)
Affinity DataKi:  7nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490784(9-[(4S,6R,7S,11aR,13R,14R,14aR,15R)-13-(6-amino-9H...)
Affinity DataKi:  8nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490799(US10968242, Example 21 Peak 2)
Affinity DataKi:  8nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490788(US10968242, Example 16 Peak 2)
Affinity DataKi:  9nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389116(CHEMBL2064561)
Affinity DataKi:  12nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389117(CHEMBL2064562)
Affinity DataKi:  13nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490780(US10968242, Example 7 Peak 3)
Affinity DataKi:  13nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490775(US10968242, Example 3 Peak 2)
Affinity DataKi:  18nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490792(US10968242, Example 19 Peak 1)
Affinity DataKi:  22nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389113(CHEMBL2064558)
Affinity DataKi:  30nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389120(CHEMBL2064565)
Affinity DataKi:  31nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490785(US10968242, Example 15 Peak 1)
Affinity DataKi:  37nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490797(US10968242, Example 20 Peak 2)
Affinity DataKi:  38nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490769(US10968242, Example 1 Peak 4)
Affinity DataKi:  42nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKi:  44nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490795(US10968242, Example 19 Peak 4)
Affinity DataKi:  54nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389109(CHEMBL2064557)
Affinity DataKi:  64nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389119(CHEMBL2064564)
Affinity DataKi:  68nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490771(US10968242, Example 2 Peak 2)
Affinity DataKi:  73nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389118(CHEMBL2064563)
Affinity DataKi:  98nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490778(US10968242, Example 7 Peak 1 | US10968242, Example...)
Affinity DataKi:  107nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490767(US10968242, Example 1 Peak 3)
Affinity DataKi:  107nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490798(US10968242, Example 21 Peak 1)
Affinity DataKi:  142nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389115(CHEMBL2064560)
Affinity DataKi:  207nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490800(9,9′-((4S,6R,7S,11aR,13R,14R,14aR,15R)-14-fl...)
Affinity DataKi:  222nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490796(US10968242, Example 20 Peak 1)
Affinity DataKi:  294nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389114(CHEMBL2064559)
Affinity DataKi:  512nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490793(US10968242, Example 19 Peak 2)
Affinity DataKi: >1.00E+3nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490783(US10968242, Example 13 Peak 2)
Affinity DataKi: >1.00E+3nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490782(US10968242, Example 13 Peak 1)
Affinity DataKi: >1.00E+3nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389117(CHEMBL2064562)
Affinity DataKi:  1.16E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490801((4S,6R,7S,11aR,13R,14R,14aR,15R)-6,13-bis(6-amino-...)
Affinity DataKi:  1.26E+3nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389113(CHEMBL2064558)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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