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Found 670 with Last Name = 'amaudrut' and Initial = 'j'
LigandPNGBDBM50615001(CHEMBL5267582)
Affinity DataIC50:  2nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615002(CHEMBL5282278)
Affinity DataIC50:  3nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50406432(CHEMBL5288562)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50614997(CHEMBL5281311)
Affinity DataIC50:  3nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615015(CHEMBL5289856)
Affinity DataIC50:  4nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615005(CHEMBL5291336)
Affinity DataIC50:  4nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615009(CHEMBL5271919)
Affinity DataIC50:  4nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615013(CHEMBL5268577)
Affinity DataIC50:  4nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50546219(CHEMBL4752026 | US11596633, Compound B | US1170239...)
Affinity DataIC50:  4nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406430(CHEMBL5274747)
Affinity DataIC50:  4nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406429(CHEMBL5276842)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50615006(CHEMBL5290261)
Affinity DataIC50:  5nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615004(CHEMBL5275370)
Affinity DataIC50:  5nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615008(CHEMBL5273026)
Affinity DataIC50:  5nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615016(CHEMBL5272403)
Affinity DataIC50:  5nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614995(CHEMBL5270277)
Affinity DataIC50:  5nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615003(CHEMBL5278658)
Affinity DataIC50:  6nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614996(CHEMBL5290513)
Affinity DataIC50:  6nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50406431(CHEMBL5278011)
Affinity DataIC50:  6nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50615014(CHEMBL5270851)
Affinity DataIC50:  6nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615011(CHEMBL5278669)
Affinity DataIC50:  7nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614994(CHEMBL5275479)
Affinity DataIC50:  8nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615007(CHEMBL5283063)
Affinity DataIC50:  9nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614992(CHEMBL5290180)
Affinity DataIC50:  9nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614988(CHEMBL5269824)
Affinity DataIC50:  9nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615012(CHEMBL5275866)
Affinity DataIC50:  10nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615002(CHEMBL5282278)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615017(CHEMBL5285837)
Affinity DataIC50:  12nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614987(CHEMBL5271480)
Affinity DataIC50:  17nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615001(CHEMBL5267582)
Affinity DataIC50:  24nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615000(CHEMBL5277819)
Affinity DataIC50:  34nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614995(CHEMBL5270277)
Affinity DataIC50:  42nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50406376(CHEMBL5289332)
Affinity DataIC50:  47nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50615010(CHEMBL5287742)
Affinity DataIC50:  49nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614986(CHEMBL5278251)
Affinity DataIC50:  54nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614999(CHEMBL5286868)
Affinity DataIC50:  55nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614997(CHEMBL5281311)
Affinity DataIC50:  58nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50406428(CHEMBL5289545)
Affinity DataIC50:  64nMAssay Description:In vitro inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50614991(CHEMBL5270502)
Affinity DataIC50:  65nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614990(CHEMBL5275625)
Affinity DataIC50:  68nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50:  71nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
LigandPNGBDBM50406374(CHEMBL5266583)
Affinity DataIC50:  74nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50614984(CHEMBL5282533)
Affinity DataIC50:  94nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293258(US10106501, Example DO | US10106501, Example DT)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293259(US10106501, Example DP)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293209(US10106501, Example CJ | US10106501, Example DQ)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292883(US10106501, Example DR | US10106501, Example R)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292869(US10106501, Example DS | US10106501, Example J)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293258(US10106501, Example DO | US10106501, Example DT)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292884(US10106501, Example S)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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