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Found 1742 with Last Name = 'dou' and Initial = 'j'
TargetCollagenase 3(Homo sapiens (Human))
Novartis

LigandPNGBDBM30369(piperidinyl glycine derivative, 24f)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/mole IC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Novartis

LigandPNGBDBM11863(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Affinity DataKi:  0.280nM ΔG°:  -54.0kJ/mole IC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50162625(Benzyl derivative of M6G | CHEMBL366917)
Affinity DataKi:  0.5nMAssay Description:Inhibition of [3H]-DAMGO binding to recombinant human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis

LigandPNGBDBM30344(Cipemastat | Trocade)
Affinity DataKi:  0.530nM ΔG°:  -52.4kJ/mole IC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM239078(US9416103, TV-5-157)
Affinity DataKi:  0.810nMAssay Description:Agonist activity at human CB2 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  1.27nM ΔG°:  -50.3kJ/mole IC50:  1.90nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM239078(US9416103, TV-5-157)
Affinity DataKi:  1.70nMAssay Description:Agonist activity at CB1 receptor in mouse Neuro2a cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50374634(CHEMBL258098)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  2.04nMAssay Description:Inhibition of Abl by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50374645(CHEMBL272939)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50162622(CHEMBL362202 | Deprotected cogener of M6G)
Affinity DataKi:  3.5nMAssay Description:Inhibition of [3H]-DAMGO binding to recombinant human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  4.19nMAssay Description:Inhibition of Lyn by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50162624(CHEMBL359644 | M6G thiosaccharide analogue)
Affinity DataKi:  5.40nMAssay Description:Inhibition of [3H]-DAMGO binding to recombinant human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  5.97nMAssay Description:Inhibition of Yes by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50496725(CHEMBL3219933)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50496728(CHEMBL3219937)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  7.22nMAssay Description:Inhibition of Src by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  7.27nMAssay Description:Inhibition of EphB4 by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  8nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50162626(CHEMBL359534 | M6G thiosaccharide analogue)
Affinity DataKi:  8.70nMAssay Description:Inhibition of [3H]-DAMGO binding to recombinant human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM85804(1-Naphthyl(1-butyl-1H-indole-3-yl)methanone | JWH-...)
Affinity DataKi:  9.80nMAssay Description:Agonist activity at human CB2 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM239077(US9416103, TV-5-249)
Affinity DataKi:  11nMAssay Description:Agonist activity at human CB2 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  11.7nMAssay Description:Inhibition of Lck by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  12.9nMAssay Description:Inhibition of Yes by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  12.9nMAssay Description:Inhibition of Yes kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50370478(MORPHINE-6-GLUCURONIDE | Morphine 6-Glucuronide(Mi...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-DAMGO binding to recombinant human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM85804(1-Naphthyl(1-butyl-1H-indole-3-yl)methanone | JWH-...)
Affinity DataKi:  13nMAssay Description:Agonist activity at CB1 receptor in mouse Neuro2a cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM239077(US9416103, TV-5-249)
Affinity DataKi:  15nMAssay Description:Agonist activity at CB1 receptor in mouse Neuro2a cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  19.4nMAssay Description:Inhibition of Abl by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  19.4nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  20nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13122((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  23nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM239075(US9416103, JWH-073-M4)
Affinity DataKi:  24nMAssay Description:Agonist activity at CB1 receptor in mouse Neuro2a cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  25.9nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  25.9nMAssay Description:Inhibition of Lyn by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50491525(CHEMBL2380408)
Affinity DataKi:  27nMAssay Description:Agonist activity at human CB2 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13133((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  28nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  28.1nMAssay Description:Inhibition of Src by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  28.1nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13121((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  29nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  29.4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  29.4nMAssay Description:Inhibition of Lck by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13127((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  31nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  33nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  34nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13119((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  36nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50491525(CHEMBL2380408)
Affinity DataKi:  37nMAssay Description:Agonist activity at CB1 receptor in mouse Neuro2a cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13100(2-[(2-cyclohexylethyl)(4-methoxybenzene)sulfonamid...)
Affinity DataKi:  38nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM13135((2R,3S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-...)
Affinity DataKi:  39nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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