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TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341578(3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphen...)
Affinity DataKi:  0.0250nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341575(7-Chloro-3-(3,5-dimethylphenyl)-6-(1-methyl-1H-pyr...)
Affinity DataKi:  0.0250nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341572(3-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Affinity DataKi:  0.0370nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341574(3-{7-Chloro-3-(3,5-dimethylphenyl)-4-[2-(piperidin...)
Affinity DataKi:  0.0380nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341562(7-chloro-6-(4-chlorophenyl)-3-(3,5-dimethylphenyl)...)
Affinity DataKi:  0.0620nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341577(3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphen...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341571(4-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341573(CHEMBL1766098 | {4-[7-Chloro-3-(3,5-dimethylphenyl...)
Affinity DataKi:  0.100nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341570(7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...)
Affinity DataKi:  0.110nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341569(7-Chloro-3-(3,5-dimethylphenyl)-6-(6-fluoropyridin...)
Affinity DataKi:  0.120nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341568(7-Chloro-6-(6-chloropyridin-3-yl)-3-(3,5-dimethylp...)
Affinity DataKi:  0.130nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341580(CHEMBL1766105 | [(4-{2-[(2R)-Piperidin-2-yl]ethoxy...)
Affinity DataKi:  0.130nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341579(CHEMBL1766104 | {3-[7-Chloro-6-(1-methyl-1H-pyrazo...)
Affinity DataKi:  0.130nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341564(7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...)
Affinity DataKi:  0.130nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341563(7-chloro-3-(3,5-dimethylphenyl)-6-phenyl-4-(2-(pip...)
Affinity DataKi:  0.180nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341565(5-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Affinity DataKi:  0.270nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341566(5-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Affinity DataKi:  0.600nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341567(7-Chloro-3-(3,5-dimethylphenyl)-6-(6-methoxypyridi...)
Affinity DataKi:  0.650nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341576((S)-7-chloro-3-(3,5-dimethylphenyl)-6-(1-methyl-1H...)
Affinity DataKi:  1.5nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341560((R)-7-chloro-3-(3,5-dimethylphenyl)-6-(4-fluorophe...)
Affinity DataKi:  1.5nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143464(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341561((R)-7-chloro-3-(3,5-dimethylphenyl)-4-(2-(piperidi...)
Affinity DataKi:  20nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143458((4S,5R)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143459((4S,5R)-3-Cyclohexyl-1-((R)-2-{2-cyclohexyl-2-[(hy...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143472((4S,5R)-3-sec-Butyl-1-((R)-2-{2-cyclohexyl-2-[(hyd...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143470(2-((S)-3-{[(4S,5R)-3-sec-Butyl-1-((R)-3-methyl-2-{...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143469((4S,5S)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...)
Affinity DataKi:  150nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143471((4S,5S)-2-[1-((S)-(S)-1-Carboxy-2-phenyl-ethylamin...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143473(2-((S)-3-{[(4S,5S)-3-Allyl-1-((R)-3-methyl-2-{(R)-...)
Affinity DataKi:  210nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143462(2-((S)-3-{[(4S,5S)-3-Ethyl-1-((R)-3-methyl-2-{(R)-...)
Affinity DataKi:  220nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143467((4S,5R)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...)
Affinity DataKi:  250nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143466((4S,5S)-3-Benzyl-1-((R)-2-{2-cyclohexyl-2-[(hydrox...)
Affinity DataKi:  310nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143468((4S,5R)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...)
Affinity DataKi:  330nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143460((2S,3R)-3-tert-Butyl-1-((R)-2-{(R)-2-cyclohexyl-2-...)
Affinity DataKi:  460nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141219(CHEMBL407433 | Pyrazine-2-carboxylic acid [(R)-1-(...)
Affinity DataKi:  920nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143465(2-((S)-3-{[(4S,5S)-1-((R)-3-Methyl-2-{(R)-3-methyl...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143461((S)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin-2-y...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143463(CHEMBL177235 | Pyrazine-2-carboxylic acid [(R)-2-m...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341559(7-chloro-3-(3,5-dimethylphenyl)-4-(2-(piperidin-2-...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341565(5-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Affinity DataIC50:  0.290nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341577(3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphen...)
Affinity DataIC50:  0.380nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341571(4-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Affinity DataIC50:  0.380nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341574(3-{7-Chloro-3-(3,5-dimethylphenyl)-4-[2-(piperidin...)
Affinity DataIC50:  0.390nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341572(3-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Affinity DataIC50:  1.10nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341559(7-chloro-3-(3,5-dimethylphenyl)-4-(2-(piperidin-2-...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at GnRH receptor by GnRHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341569(7-Chloro-3-(3,5-dimethylphenyl)-6-(6-fluoropyridin...)
Affinity DataIC50:  4.70nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341578(3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphen...)
Affinity DataIC50:  4.80nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341575(7-Chloro-3-(3,5-dimethylphenyl)-6-(1-methyl-1H-pyr...)
Affinity DataIC50:  4.80nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341563(7-chloro-3-(3,5-dimethylphenyl)-6-phenyl-4-(2-(pip...)
Affinity DataIC50:  7.60nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50341564(7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...)
Affinity DataIC50:  8.30nMAssay Description:Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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