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Found 2539 with Last Name = 'rein' and Initial = 'j'
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111728(4-Fluoro-2-({1-[((R)-1-formyl-4-guanidino-butylcar...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111741(CHEMBL19666 | N-(5-Carbamimidoyl-thiophen-2-ylmeth...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111729(CHEMBL277695 | N-(5-Carbamimidoyl-thiophen-2-ylmet...)
Affinity DataKi:  0.120nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111730(2-[3-(2-Fluoro-phenylmethanesulfonylamino)-6-methy...)
Affinity DataKi:  0.140nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50016816(CHEMBL412913 | S-S-C-F-G-G-R-I-D-R-I-G-A-Q-S-G-L-G...)
Affinity DataKi:  0.25nMAssay Description:Apparent binding affinity for non-vasorelaxant receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019((R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperaz...)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]paraxetine from human 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50316949((3R)-3-((3-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111724(CHEMBL19731 | N-(4-Carbamimidoyl-benzyl)-2-(6-meth...)
Affinity DataKi:  0.370nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50302220(7-((1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162026(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261243((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019((R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperaz...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111717(2-[3-(2-Fluoro-phenylmethanesulfonylamino)-2-oxo-2...)
Affinity DataKi:  0.560nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111726(CHEMBL19359 | N-(4-Carbamimidoyl-benzyl)-2-(6-meth...)
Affinity DataKi:  0.570nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149255(3-((R)-2-Cyclopentyl-2-dimethylamino-ethyl)-1-(2,6...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162008((R)-1-(2-chloro-6-fluorobenzyl)-3-(2-amino-2-pheny...)
Affinity DataKi:  0.610nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50423641(A-198401 | CHEMBL303274)
Affinity DataKi:  0.631nMAssay Description:Ability of compound to inhibit [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt]GnRH agonist binding to the rat Gonadotropin-releasing hormone receptor was evaluate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166450((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50067796(CHEMBL11157 | L-374087 | N-((6-amino-2-methylpyrid...)
Affinity DataKi:  0.680nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50144640(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-chloro-6-fluor...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards human gonadotropin-releasing hormone receptor expressed in HEK293 cells using des-Gly10-[125I]Tyr,5 DLeu,6 NMeLeu,7 Pro9-NEt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50067796(CHEMBL11157 | L-374087 | N-((6-amino-2-methylpyrid...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluo...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-(4-(4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019((R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperaz...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-(4-(4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]paraxetine from human 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50033422(CHEMBL3357688)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50274930((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50081157((S)-1-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-...)
Affinity DataKi:  1nMAssay Description:Evaluation of inhibition of transition state thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071693(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)
Affinity DataKi:  1nMAssay Description:Evaluation of inhibition of transition state thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019((R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperaz...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50067797(CHEMBL19080 | L-37378 | N-(6-Amino-2-methyl-pyridi...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111739(CHEMBL19811 | N-((S)-2-Amino-1,4,5,6-tetrahydro-py...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50067797(CHEMBL19080 | L-37378 | N-(6-Amino-2-methyl-pyridi...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50081158(2-((R)-3-Amino-3-benzyl-2-oxo-piperidin-1-yl)-N-((...)
Affinity DataKi:  1nMAssay Description:Evaluation of inhibition of transition state thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50274931((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50109235(7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50111738(CHEMBL274968 | N-((4R,5S)-2-Amino-4-methyl-1,4,5,6...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50260759((R)-4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50127191(2-(8-(2-Fluoro-benzyl)-6-(3-methoxy-phenyl)-7-meth...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50109234(7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149263(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149263(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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