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Found 237 with Last Name = 'reymond' and Initial = 'j'
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNatural resistance-associated macrophage protein 2(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50387726(CHEMBL2058878)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50327886((1R,2S,5S,6S)-3-azabicyclo[3.1.0]hexane-2,6-dicarb...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50197105((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50327885((2S,3S)-pyrrolidine-2,3-dicarboxylic acid | CHEMBL...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50180145((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Aurora B kinase in human HeLa Kyoto cells assessed as effect on distribution of phspho-histone H3 ser10 level incubated for 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50:  2nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198081(CHEMBL3915550)
Affinity DataIC50:  4nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198080(CHEMBL3932394)
Affinity DataIC50:  6nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198082(CHEMBL3904239)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198086(CHEMBL3985313)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50: >10nMAssay Description:Inhibition of Aurora B kinase in human HeLa Kyoto cells assessed as effect on distribution of phspho-histone H3 ser10 level incubated for 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198052(CHEMBL3896597)
Affinity DataIC50:  24nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198052(CHEMBL3896597)
Affinity DataIC50:  24nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198044(CHEMBL3903187)
Affinity DataIC50:  25nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50502759(CHEMBL4435596)
Affinity DataIC50:  50nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50550080(CHEMBL4796516)
Affinity DataIC50:  64nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391599(ETI-T-351 | US10300048, Compound 1 | US10300048, E...)
Affinity DataIC50:  68nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391624(US10300048, ETI-T-351)
Affinity DataIC50:  68nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391600(ETI-T-255 | US10300048, Compound 2 | US10300048, E...)
Affinity DataIC50:  74nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391600(ETI-T-255 | US10300048, Compound 2 | US10300048, E...)
Affinity DataIC50:  74nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50550078(CHEMBL4777551)
Affinity DataIC50:  82nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198045(CHEMBL3975102)
Affinity DataIC50:  130nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50550077(CHEMBL4789936)
Affinity DataIC50:  130nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391601(ETI-T-045 | US10300048, Compound 3)
Affinity DataIC50:  138nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNatural resistance-associated macrophage protein 2(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50387726(CHEMBL2058878)
Affinity DataIC50:  140nMAssay Description:Inhibition of human DMT1 expressed in Xenopus oocytes assessed as inhibition of channel currents at -50 mV holding potential by two-electrode voltage...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391626(US10300048, ETI-T-424)
Affinity DataIC50:  145nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391602(ETI-T-424 | US10300048, Compound 4)
Affinity DataIC50:  145nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391603(ETI-T-174 | US10300048, Compound 5)
Affinity DataIC50:  148nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391627(US10300048, ETI-T-174)
Affinity DataIC50:  148nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50:  150nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50550081(CHEMBL4740003)
Affinity DataIC50:  150nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50550082(CHEMBL4760109)
Affinity DataIC50:  170nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198079(CHEMBL3924918)
Affinity DataIC50:  190nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198078(CHEMBL3941377)
Affinity DataIC50:  190nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Berne

Curated by ChEMBL
LigandPNGBDBM50198084(CHEMBL3913242)
Affinity DataIC50:  220nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391604(ETI-T-348 | US10300048, Compound 6)
Affinity DataIC50:  225nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391628(US10300048, ETI-T-348)
Affinity DataIC50:  225nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFucose-binding lectin PA-IIL(Pseudomonas aeruginosa)
Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50509063(CHEMBL4515649)
Affinity DataIC50:  249nMAssay Description:Inhibition of Pseudomonas aeruginosa LecB by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391629(US10300048, ETI-T-365)
Affinity DataIC50:  266nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391605(ETI-T-365 | US10300048, Compound 7)
Affinity DataIC50:  266nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universitat Bern

US Patent
LigandPNGBDBM391630(US10300048, ETI-T-413)
Affinity DataIC50:  268nMAssay Description:Screening for AEA cellular uptake inhibition was performed in a semi-automated procedure: Pipetting and washing steps were performed by a Biomek3000 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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