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Found 2659 with Last Name = 'roa' and Initial = 'j'
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50248793(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi:  0.0700nMAssay Description:Compound was evaluated for binding affinity against [3H]- DAMGO labeled mu opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50027230(CHEMBL2113666)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant DOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50287928(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for binding affinity against [3H]- DAMGO labeled mu opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  0.110nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193546(14beta-(2'-methylcinnamoylamino)-7,8-dihydromorphi...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant DOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50027230(CHEMBL2113666)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50287928(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for binding affinity against [3H]- U-69593 labeled kappa1 opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50248793(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for binding affinity against [3H]- U-69593 labeled kappa1 opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50398951(CHEMBL2179258)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50193536(N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamin...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to MOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50033649(1N-[10-hydroxy-4-methyl-14-oxo-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  0.200nMAssay Description:Stimulation of [35S]GTPgammaS binding to human recombinant MORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50451852(CHEMBL1159649)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85790(Salmon MCH)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50287927(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for binding affinity against [3H]- DAMGO labeled mu opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193546(14beta-(2'-methylcinnamoylamino)-7,8-dihydromorphi...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193546(14beta-(2'-methylcinnamoylamino)-7,8-dihydromorphi...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]U-69593 from human recombinant KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50287929(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  0.230nMAssay Description:Compound was evaluated for binding affinity against [3H]- DAMGO labeled mu opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50398952(CHEMBL2179264)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145355(1-{2-[4-(6,7-Dichloro-1H-indol-3-yl)-3,6-dihydro-2...)
Affinity DataKi:  0.280nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145343(1-{2-[4-(6-Fluoro-benzofuran-3-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  0.290nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145356(1-{2-[4-(6,7-Difluoro-1H-indol-3-yl)-3,6-dihydro-2...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50366907(CHEMBL1169435)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85789([Phe13,Tyr19]MCH)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195678((1R,5R,13R,17S)-17-{[(2E)-3-(4-chlorophenyl)prop-2...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193542(17-methyl-4'-methyldihydromorphinone)
Affinity DataKi:  0.340nMAssay Description:Stimulation of [35S]GTPgammaS binding to human recombinant MORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193544(N-[(1R,13R,17S)-10-hydroxy-4-methyl-14-oxo-12-oxa-...)
Affinity DataKi:  0.350nMAssay Description:Stimulation of [35S]GTPgammaS binding to human recombinant MORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145342(1-{2-[4-(6-Chloro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.380nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193549(14beta-(2'-methylcinnamoylamino)-7,8-dihydrocodein...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50247803(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Affinity DataKi:  0.400nMAssay Description:Compound was evaluated for binding affinity against [3H]- DAMGO labeled mu opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50247803(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50248968(14beta-Cinnamoyloxy-N-cyclopropylmethyl-7,8-dihydr...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]U-69593 from human recombinant KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193549(14beta-(2'-methylcinnamoylamino)-7,8-dihydrocodein...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant DOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193540(14beta-(4'-methylcinnamoylamino)-7,8-dihydrocodein...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50398950(CHEMBL2179259)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]U69593 from KOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145354(1-{2-[4-(6-Fluoro-1H-indazol-3-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  0.5nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50398952(CHEMBL2179264)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]U69593 from KOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50027230(CHEMBL2113666)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]U-69593 from human recombinant KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50033649(1N-[10-hydroxy-4-methyl-14-oxo-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant DOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145350(1-{2-[4-(6-Fluoro-1-methyl-1H-indazol-3-yl)-3,6-di...)
Affinity DataKi:  0.540nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193544(N-[(1R,13R,17S)-10-hydroxy-4-methyl-14-oxo-12-oxa-...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]U-69593 from human recombinant KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193547(14beta-(2'-chlorocinnamoylamino)-7,8-dihydrocodein...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant DOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50193538(14beta-(4'-chlorocinnamoylamino)-7,8-dihydrocodein...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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