TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 282nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Tufts University
Curated by ChEMBL
Tufts University
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Displacement of fluorescent pTyr from recombinant His6-tagged human STAT3 (codons 127-711) expressed in Escherichia coli BL21 Rosetta after 45 mins b...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Tufts University
Curated by ChEMBL
Tufts University
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Displacement of fluorescent pTyr from recombinant His6-tagged human STAT3 (codons 127-711) expressed in Escherichia coli BL21 Rosetta after 45 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 4.11E+3nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Tufts University
Curated by ChEMBL
Tufts University
Curated by ChEMBL
Affinity DataIC50: 7.10E+3nMAssay Description:Displacement of fluorescent pTyr from recombinant His6-tagged human STAT3 (codons 127-711) expressed in Escherichia coli BL21 Rosetta after 45 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 8.43E+3nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 2.71E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.79E+4nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.89E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 5.55E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 6.28E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: >6.70E+4nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 6.88E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 7.65E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 8.81E+4nMAssay Description:Inhibition of fluorescence-labelled cNPF1 probe binding to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 9.45E+4nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity to GST-fused Eps15 EH2 domain (unknown origin) expressed in Escherichia coli BL21 cells under high salt condition by fluorescence po...More data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+5nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+5nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+5nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.68E+5nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.31E+5nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
Affinity DataIC50: 2.33E+5nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.14E+5nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKon: 0.00690M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKd: 17nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKd: 7.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKon: 0.00420M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKon: 0.0110M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
Affinity DataKd: 3.00E+3nMAssay Description:Binding affinity to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells measured after 1 hr in presence of 15 mM NaCl ...More data for this Ligand-Target Pair
Affinity DataKd: 1.51E+4nMAssay Description:Binding affinity to GST-fused EHD1 EH domain (unknown origin) expressed in Escherichia coli BL21 cells measured after 1 hr in presence of 150 mM NaCl...More data for this Ligand-Target Pair