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Found 32 with Last Name = 'kauer' and Initial = 'jc'
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  0.0160nMAssay Description:Inhibition of cAMP dependent Protein kinase A of rabbit Skeletal Muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031442(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  2nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50031442(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  2.40nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031440(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  6nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50031440(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  6nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288611(Alpha-ketocarbonyl boronic ester derivative | CHEM...)
Affinity DataIC50:  8nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058332(CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...)
Affinity DataIC50: >10nMAssay Description:Inhibition of cAMP dependent Protein kinase A of rabbit Skeletal Muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058332(CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...)
Affinity DataIC50: >10nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity of compound against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50470197(CHEMBL2114122)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288609(Alpha-ketocarbonyl derivative | CHEMBL317337)
Affinity DataIC50:  22nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288609(Alpha-ketocarbonyl derivative | CHEMBL317337)
Affinity DataIC50:  22nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287391((R)-4-Methyl-2-[2-oxo-2-(9H-xanthen-9-yl)-ethyl]-p...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity of compound against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50470199(CHEMBL76284)
Affinity DataIC50:  40nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287394((R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid (...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity of compound against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50470198(CHEMBL73602)
Affinity DataIC50:  95nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287392((R)-4-Methyl-2-[2-oxo-2-(9H-xanthen-9-yl)-ethyl]-p...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity of compound against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287390((R)-2-Isobutyl-4-oxo-8-phenyl-octanoic acid ((S)-1...)
Affinity DataIC50:  138nMAssay Description:Inhibitory activity of compound against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058336(CHEMBL53885 | methyl 10,23-di(ethoxymethyl)-16-hyd...)
Affinity DataIC50:  210nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287393(CHEMBL296285 | [(S)-1-(1-Ethylaminooxalyl-propylca...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activity of compound against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058333(CHEMBL291985 | methyl 16-hydroxy-10,23-di(methoxym...)
Affinity DataIC50:  270nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288610(Alpha-ketocarbonyl derivative | CHEMBL98937)
Affinity DataIC50: >1.00E+3nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058329(CHEMBL55567 | methyl 16-hydroxy-15-methyl-3-oxo-10...)
Affinity DataIC50: >1.00E+3nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058331(CHEMBL444039 | methyl 10,23-di(butylsulfanylmethyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288610(Alpha-ketocarbonyl derivative | CHEMBL98937)
Affinity DataIC50: >1.00E+3nMAssay Description:Compound was tested for thromboxane TXA2 synthase inhibitory activity using human plateletMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058334(CHEMBL301144 | methyl 16-hydroxy-10,23-di(isopropy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058335(CHEMBL433281 | methyl 10,23-di(allylsulfanylmethyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058332(CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470200(CHEMBL2369773)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470201(CHEMBL406736)
Affinity DataIC50: >3.00E+3nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed