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Found 175 with Last Name = '??tka' and Initial = 'k'
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519413(CHEMBL4475205)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519409(CHEMBL4554399)
Affinity DataKi:  83nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor stably expressed in CHOK1 cells after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519407(CHEMBL4529681)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519411(CHEMBL4518890)
Affinity DataKi:  111nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor stably expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519412(CHEMBL4474399)
Affinity DataKi:  129nMAssay Description:Non-competitive inhibition of recombinant human AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519412(CHEMBL4474399)
Affinity DataKi:  129nMAssay Description:Non-competitive inhibition of recombinant human AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataKi:  176nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataKi:  178nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519408(CHEMBL4454949)
Affinity DataKi:  182nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519412(CHEMBL4474399)
Affinity DataKi:  228nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataKi:  281nMAssay Description:Non-competitive inhibition of equine serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataKi:  282nMAssay Description:Non-competitive inhibition of equine serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519404(CHEMBL4560469)
Affinity DataKi:  523nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519415(CHEMBL4449159)
Affinity DataKi:  690nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor stably expressed in CHOK1 cells after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519410(CHEMBL4542364)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor stably expressed in CHOK1 cells after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519405(CHEMBL4551064)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor stably expressed in CHOK1 cells after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519414(CHEMBL4457277)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor stably expressed in CHOK1 cells after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50563999(CHEMBL4595698)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of [3H]NO711 binding to mouse GAT1 expressed in human HEK293 cell line by MS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50563999(CHEMBL4595698)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of mouse GAT1 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition meas...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  32nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataIC50:  37nMAssay Description:Inhibition of [3H]NO711 binding to mouse GAT1 expressed in human HEK293 cell line by MS binding assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  41nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  131nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition meas...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataIC50:  132nMAssay Description:Inhibition of mouse GAT1 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519412(CHEMBL4474399)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataIC50:  440nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataIC50:  460nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519406(CHEMBL4455690)
Affinity DataIC50:  480nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519412(CHEMBL4474399)
Affinity DataIC50:  500nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519412(CHEMBL4474399)
Affinity DataIC50:  760nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519413(CHEMBL4475205)
Affinity DataIC50:  800nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519404(CHEMBL4560469)
Affinity DataIC50:  800nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519413(CHEMBL4475205)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577088(CHEMBL4860085)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519404(CHEMBL4560469)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519407(CHEMBL4529681)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50078167(CHEMBL69064)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mouse GAT1 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50563998(CHEMBL4781266)
Affinity DataIC50:  2.46E+3nMAssay Description:Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50519408(CHEMBL4454949)
Affinity DataIC50:  3.92E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577081(CHEMBL4852705)
Affinity DataIC50:  4.37E+3nMAssay Description:Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577088(CHEMBL4860085)
Affinity DataIC50:  4.37E+3nMAssay Description:Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50563998(CHEMBL4781266)
Affinity DataIC50:  4.47E+3nMAssay Description:Inhibition of mouse GAT2 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577077(CHEMBL4854996)
Affinity DataIC50:  4.57E+3nMAssay Description:Inhibition of mouse GAT2 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577078(CHEMBL4854550)
Affinity DataIC50:  4.68E+3nMAssay Description:Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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