Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
Affinity DataIC50: 960nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of beta2 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+3nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+3nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+3nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-II(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A2 RNA dependent ATPase activity using single stranded poly...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
TargetU5 small nuclear ribonucleoprotein 200 kDa helicase(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...More data for this Ligand-Target Pair
TargetU5 small nuclear ribonucleoprotein 200 kDa helicase(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-II(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A2 RNA dependent ATPase activity using single stranded poly...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
TargetU5 small nuclear ribonucleoprotein 200 kDa helicase(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...More data for this Ligand-Target Pair