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Found 365 with Last Name = 'yuan' and Initial = 'k'
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054826(CHEMBL144474 | [7-([4,4']Bipiperidinyl-1-carbonyl)...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054827(CHEMBL85094 | SB-208651 | {8-[(4-Carbamimidoyl-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)
Affinity DataKi:  2nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054830(CHEMBL356986 | [(R)-7-([4,4']Bipiperidinyl-1-carbo...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036088(CHEMBL18734 | [(6S,13S)-13-(3-Guanidino-propyl)-14...)
Affinity DataKi:  2.80nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036089(CHEMBL18288 | [8-(4-Carbamimidoyl-phenylcarbamoyl)...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036088(CHEMBL18734 | [(6S,13S)-13-(3-Guanidino-propyl)-14...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036088(CHEMBL18734 | [(6S,13S)-13-(3-Guanidino-propyl)-14...)
Affinity DataKi:  3.5nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054831(CHEMBL143219 | [7-([4,4']Bipiperidinyl-1-carbonyl)...)
Affinity DataKi:  4nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054824(CHEMBL144681 | {7-[Methyl-(3-piperidin-4-yl-propyl...)
Affinity DataKi:  8nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059127(CHEMBL74081 | [4-Methyl-3-oxo-7-(4-pyridin-4-yl-pi...)
Affinity DataKi:  8nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059129(CHEMBL2369779 | N-{3-[8-Benzyl-5-isopropyl-3,6,9,1...)
Affinity DataKi:  10nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059129(CHEMBL2369779 | N-{3-[8-Benzyl-5-isopropyl-3,6,9,1...)
Affinity DataKi:  10nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059136(CHEMBL73078 | {(S)-7-[(1H-Benzoimidazol-2-ylmethyl...)
Affinity DataKi:  15nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059130(CHEMBL74992 | {7-[(1H-Benzoimidazol-2-ylmethyl)-ca...)
Affinity DataKi:  24nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054829(CHEMBL306110 | [7-(3-Carbamimidoyl-phenylcarbamoyl...)
Affinity DataKi:  26nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036086(CHEMBL18911 | [7-(4-Carbamimidoyl-phenylcarbamoyl)...)
Affinity DataKi:  26nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059131((5-{[(S)-2-(Benzoyl-methyl-amino)-5-guanidino-pent...)
Affinity DataKi:  50nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054828(CHEMBL143394 | {7-[(3-Carbamimidoyl-phenyl)-methyl...)
Affinity DataKi:  90nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059131((5-{[(S)-2-(Benzoyl-methyl-amino)-5-guanidino-pent...)
Affinity DataKi:  110nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054829(CHEMBL306110 | [7-(3-Carbamimidoyl-phenylcarbamoyl...)
Affinity DataKi:  510nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059127(CHEMBL74081 | [4-Methyl-3-oxo-7-(4-pyridin-4-yl-pi...)
Affinity DataKi:  1.00E+3nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059132(CHEMBL73703 | {7-[2-(1H-Benzoimidazol-2-yl)-ethylc...)
Affinity DataKi:  1.10E+3nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059134(CHEMBL73811 | [7-(1H-Benzoimidazol-2-ylcarbamoyl)-...)
Affinity DataKi:  1.15E+3nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054825(CHEMBL356301 | [(S)-7-([4,4']Bipiperidinyl-1-carbo...)
Affinity DataKi:  1.53E+3nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059126(CHEMBL72941 | {(R)-7-[(1H-Benzoimidazol-2-ylmethyl...)
Affinity DataKi:  4.20E+3nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054829(CHEMBL306110 | [7-(3-Carbamimidoyl-phenylcarbamoyl...)
Affinity DataKi:  4.50E+3nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059128(CHEMBL74880 | [4-Methyl-3-oxo-7-(4-phenyl-piperazi...)
Affinity DataKi:  9.20E+3nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)
Affinity DataKi:  3.00E+4nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059130(CHEMBL74992 | {7-[(1H-Benzoimidazol-2-ylmethyl)-ca...)
Affinity DataKi:  3.00E+4nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059134(CHEMBL73811 | [7-(1H-Benzoimidazol-2-ylcarbamoyl)-...)
Affinity DataKi: >5.00E+4nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059126(CHEMBL72941 | {(R)-7-[(1H-Benzoimidazol-2-ylmethyl...)
Affinity DataKi: >5.00E+4nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059132(CHEMBL73703 | {7-[2-(1H-Benzoimidazol-2-yl)-ethylc...)
Affinity DataKi: >5.00E+4nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059136(CHEMBL73078 | {(S)-7-[(1H-Benzoimidazol-2-ylmethyl...)
Affinity DataKi:  5.20E+4nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036086(CHEMBL18911 | [7-(4-Carbamimidoyl-phenylcarbamoyl)...)
Affinity DataKi:  5.60E+4nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059135(((Z)-2,20-Diamino-8-benzyl-11-hydroxymethyl-4,7,10...)
Affinity DataKi:  7.50E+4nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059135(((Z)-2,20-Diamino-8-benzyl-11-hydroxymethyl-4,7,10...)
Affinity DataKi:  7.50E+4nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059128(CHEMBL74880 | [4-Methyl-3-oxo-7-(4-phenyl-piperazi...)
Affinity DataKi: >1.00E+5nMAssay Description:Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50612938(CHEMBL5289179)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of hexa His-tagged DYRK2 (72 to 479 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as substrate phosphorylat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50075073(CHEMBL3414622)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human SET7 expressed in Escherichia coli using [3H] SAM as substrate by scintillation counter assayMore data for this Ligand-Target Pair
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human GST-tagged DYRK2 expressed in Escherichia coli BL21 (DE3) using woodtide as substrate in presence of [gamma33-P]ATP incubated for...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50588665(CHEMBL5171767)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin-D3 (unknown origin) in presence of ATP by time resolved-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50583189(CHEMBL5079648)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of [33P]-ATP incubated for 2 hrs by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50612944(CHEMBL5286478)
Affinity DataIC50:  4nMAssay Description:Inhibition of hexa His-tagged DYRK2 (72 to 479 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as substrate phosphorylat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50601118(CHEMBL5170522)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50601117(CHEMBL5174517)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in presence of [33P]-ATP incubated for 2 hrs by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621042((6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluo...)
Affinity DataIC50:  8nMAssay Description:Table 1: In the test plate, protein kinase, Ulight-labeled polypeptide substrate, ATP, and the compounds were mixed and the reaction was incubated. E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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