TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human N-terminal GST/His6-tagged GSK3beta (M1 to T420 residues) expressed in baculovirus infected sf9 cells using RBER-IRStide as subst...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of compound against thymidylate synthetaseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of compound against Guanine-7-methyl transferaseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of GSK3beta assessed as inhibition of [33Pi] incorporation after 80 mins by microplate scintillation countingMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 169nMAssay Description:Inhibition of IGF1R (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK5 (M1 to P292 residues)/p35NCK (M1 to R307 residues) expressed in baculovirus infected sf9 c...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 840nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 910nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 920nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CDK2/CyclinE (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 3.49E+3nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of IGF1R (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
University of Kaiserslautern
Curated by ChEMBL
University of Kaiserslautern
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...More data for this Ligand-Target Pair