Affinity DataKi: 1.97E+3nMAssay Description:Competitive inhibition of human KDM2A expressed in Escherichia coli using 2-oxoglutarate by enzyme kinetic assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.50E+4nMAssay Description:Mixed type inhibition of human KDM2A expressed in Escherichia coli assessed inhibition constant for compound-enzyme-substrate complex using methyl ly...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 512nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 570nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human KDM6B catalytic domain expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli by formaldehyde dehydrogenase coupled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human KDM7A catalytic domain expressed in Escherichia coli by MALDI assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human PHD2 expressed in Escherichia coli by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of human PHD2 expressed in Escherichia coli by fluorescence based assayMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of human KDM6B catalytic domain expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of human PHD2 expressed in Escherichia coli by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
Affinity DataIC50: 2.39E+4nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair