TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataKi: 2.18E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataKi: 2.22E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse HDAC1More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against maize histone deacetylase 2More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against maize histone deacetylase 2More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against maize histone deacetylase 2More data for this Ligand-Target Pair
Affinity DataIC50: 11.4nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 13.7nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMT: 2°CAssay Description:Inhibition of human recombinant HDAC6 pre-incubated at room temperature for 15 min before substrate addition by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMT: 2°CAssay Description:Inhibition of human recombinant HDAC6 pre-incubated at room temperature for 15 min before substrate addition by fluorimetric assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant JARID1C (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full length HDAC6 expressed in insect SF9 cells using fluorogenic ZMAL as substrate after 90 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of mouse HDAC1More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of mouse HDAC1More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse HDAC1More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full length HDAC6 expressed in insect SF9 cells using fluorogenic ZMAL as substrate after 90 mi...More data for this Ligand-Target Pair