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Found 119 with Last Name = 'pustilnik' and Initial = 'lr'
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485444(CHEMBL2059813)
Affinity DataIC50:  0.178nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458169(Avagacestat | BMS 708163 | BMS-708163 | BMS-708163...)
Affinity DataIC50:  0.225nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485438(CHEMBL2059021)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485443(CHEMBL2059814)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485431(CHEMBL2059815)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118009((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-2-yl-phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485434(CHEMBL2059016)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485434(CHEMBL2059016)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117952((6,7-Diethoxy-quinazolin-4-yl)-(3-furan-2-yl-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095256((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-4-fluor...)
Affinity DataIC50:  4nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485436(CHEMBL2059011)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484476(CHEMBL1916325)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484472(CHEMBL1916327)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50096851(CHEMBL3580774)
Affinity DataIC50:  6nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101747(CHEMBL3394946)
Affinity DataIC50:  6nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484455(CHEMBL1916335)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485447(CHEMBL2059819)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484467(CHEMBL1916326)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485435(CHEMBL2059014)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484460(CHEMBL1916320)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50101749(CHEMBL3394944)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484465(CHEMBL1916331)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484474(CHEMBL1916324)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50101748(CHEMBL3394945)
Affinity DataIC50:  9nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485446(CHEMBL2059015)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485445(CHEMBL2059818)
Affinity DataIC50:  11nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117983((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-5-yl-phe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117986((6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-pyrazol-3-yl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484454(CHEMBL1916334)
Affinity DataIC50:  11nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484464(CHEMBL1916330)
Affinity DataIC50:  11nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485440(CHEMBL2059020)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484458(CHEMBL1916317)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485433(CHEMBL2059018)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484470(CHEMBL1916319)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484475(CHEMBL1916329)
Affinity DataIC50:  13nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485437(CHEMBL2059820)
Affinity DataIC50:  15nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485439(CHEMBL2059012)
Affinity DataIC50:  16nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484466(CHEMBL1916332)
Affinity DataIC50:  16nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50096863(CHEMBL3580766)
Affinity DataIC50:  17nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484473(CHEMBL1916333)
Affinity DataIC50:  17nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484459(CHEMBL1916318)
Affinity DataIC50:  17nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484468(CHEMBL1916337)
Affinity DataIC50:  17nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50101800(CHEMBL3394934)
Affinity DataIC50:  17nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117970((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-4-yl-phe...)
Affinity DataIC50:  18nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50096865(CHEMBL3580764)
Affinity DataIC50:  18nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50103134(CHEMBL3394928)
Affinity DataIC50:  19nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50096853(CHEMBL3580772)
Affinity DataIC50:  20nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101792(CHEMBL3394942)
Affinity DataIC50:  22nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485430(CHEMBL2059816)
Affinity DataIC50:  23nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485441(CHEMBL2059017)
Affinity DataIC50:  24nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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