Affinity DataIC50: 13nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using Dextromethorphan as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 367nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using Diclofenac as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 810nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 810nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by fluorescence...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta ...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta ...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta ...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by fluorescence...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 3.12E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 4.23E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 4.25E+3nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by fluorescence...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 4.32E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 5.12E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by fluorescence...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 5.31E+3nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by fluorescence...More data for this Ligand-Target Pair
Affinity DataIC50: 6.43E+3nMAssay Description:Inhibition of telomerase activity in human SGC-7901 cells incubated for 24 hrs by TRAP-PCR-ELISA assayMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 6.76E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 7.01E+3nMAssay Description:Inhibition of telomerase activity in human SGC-7901 cells incubated for 24 hrs by TRAP-PCR-ELISA assayMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 7.18E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 7.26E+3nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by fluorescence...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 7.68E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
Affinity DataIC50: 7.76E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using Mephenytoin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 8.31E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 8.32E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 8.46E+3nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by fluorescence...More data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of telomerase activity in human SGC-7901 cells incubated for 24 hrs by TRAP-PCR-ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using Diclofenac as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9.25E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using Mephenytoin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 9.34E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta ...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing Agricultural University
Curated by ChEMBL
Nanjing Agricultural University
Curated by ChEMBL
Affinity DataIC50: 9.65E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 9.68E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair