Affinity DataKi: 6.90nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 58nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 109nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of mouse cathepsin S using benzyloxycarbonyl-L-Leucyl-L-Arginine 4-Methyl-coumaryl-7-amide substrate by FRET assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of mouse cathepsin S using benzyloxycarbonyl-L-Leucyl-L-Arginine 4-Methyl-coumaryl-7-amide substrate by FRET assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human cathepsin S using benzyloxycarbonyl-L-Leucyl-L-Arginine 4-Methyl-coumaryl-7-amide substrate by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human cathepsin S using benzyloxycarbonyl-L-Leucyl-L-Arginine 4-Methyl-coumaryl-7-amide substrate by FRET assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human GlyT2More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of full length human GlyT2 expressed in FreeStyle 293-F suspension cells incubated for 30 mins before [3H]glycine addition and measured af...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 105nMAssay Description:Reversible inhibition of recombinant human GlyT2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake after 2 hrs by top count assa...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 143nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 151nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 152nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
University of Sydney
Curated by ChEMBL
University of Sydney
Curated by ChEMBL
Affinity DataIC50: 214nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair