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Found 77 with Last Name = 'frauli' and Initial = 'm'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...)
Affinity DataKi:  600nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...)
Affinity DataKi:  800nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332631(CHEMBL1630804 | N-(4-Fluorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataIC50:  800nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...)
Affinity DataIC50:  1.00E+3nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...)
Affinity DataIC50:  1.50E+3nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50060137((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR2 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50:  3.78E+5nMAssay Description:Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50060137((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Affinity DataEC50:  7.20E+3nMAssay Description:Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50060137((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Affinity DataEC50:  1.20E+6nMAssay Description:Activity at rat mGluR7 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50:  5.62E+4nMAssay Description:Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50060137((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR5 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50060137((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Affinity DataEC50:  1.01E+4nMAssay Description:Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50060137((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Affinity DataEC50:  1.84E+4nMAssay Description:Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50:  4.83E+4nMAssay Description:Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50: >5.00E+6nMAssay Description:Activity at rat mGluR5 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50: >5.00E+6nMAssay Description:Activity at rat mGluR2 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Faust Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50: >5.00E+6nMAssay Description:Activity at rat mGluR1 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataEC50:  1.34E+4nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...)
Affinity DataEC50:  8.90E+3nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...)
Affinity DataEC50:  1.04E+4nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50116514(CHEMBL507522)
Affinity DataEC50:  2.25E+3nMAssay Description:Inhibitory activity against human immunodeficiency virus-1 reverse transcriptase(HIV-1 RT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50116514(CHEMBL507522)
Affinity DataEC50:  2.50E+3nMAssay Description:The compound was tested for the inhibition of human immunodeficiency virus-1 reverse transcriptase(HIV-1 RT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241541(CHEMBL4087749)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241542(CHEMBL4065348)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241543(CHEMBL4060429)
Affinity DataEC50:  3.96E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241544(CHEMBL4081595)
Affinity DataEC50:  310nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241545(CHEMBL4059644)
Affinity DataEC50:  1.27E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241546(CHEMBL4071024)
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241547(CHEMBL4097178)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241548(CHEMBL4089473)
Affinity DataEC50:  280nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241549(CHEMBL4068295)
Affinity DataEC50:  860nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241550(CHEMBL4067271)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241551(CHEMBL4088412)
Affinity DataEC50:  2.47E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241552(CHEMBL4085101)
Affinity DataEC50:  90nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241554(CHEMBL4063474)
Affinity DataEC50:  35nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241555(CHEMBL4062968)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241556(CHEMBL4083118)
Affinity DataEC50:  1.74E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241557(CHEMBL4101095)
Affinity DataEC50:  3.01E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241559(CHEMBL4093353)
Affinity DataEC50:  9.84E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241560(CHEMBL4064041)
Affinity DataEC50:  750nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241561(CHEMBL4085608)
Affinity DataEC50:  1.01E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241562(CHEMBL4103895)
Affinity DataEC50:  1.72E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241563(CHEMBL4085967)
Affinity DataEC50:  1.39E+3nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241564(CHEMBL4096136)
Affinity DataEC50:  690nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241565(CHEMBL4082167)
Affinity DataEC50:  106nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241566(CHEMBL4100168)
Affinity DataEC50:  25nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241567(CHEMBL4072094)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Prexton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50241568(CHEMBL4100586)
Affinity DataEC50:  35nMAssay Description:Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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