Compile Data Set for Download or QSAR
maximum 50k data
Found 176 with Last Name = 'maira' and Initial = 'm'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  1.90nMAssay Description:Displacement of Alexa Fluor labelled Tracer-314 from human N-terminal GST-tagged mTOR incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50380371(CHEMBL2017970)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380366(CHEMBL2017965)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380369(CHEMBL2017968)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380367(CHEMBL2017966)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50380370(CHEMBL2017969)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380372(CHEMBL2016592)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598037(CHEMBL5203121)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using L-alpha-phosphatidylinositol as substrate in presence of ATP by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598037(CHEMBL5203121)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using phosphatidylinositol as substrate measured for 15 to 60 mins by TR-FRET based Adapta universal kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  8.60nMAssay Description:Binding affinity to human N-terminal GST-tagged mTOR assessed as phosphorylated 4EBP1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50598037(CHEMBL5203121)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using L-alpha-phosphatidylinositol as substrate in presence of ATP by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50380377(CHEMBL2017977 | WO2007/084786, Compound 85)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380376(CHEMBL2017976)
Affinity DataIC50:  15nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380365(CHEMBL2017971)
Affinity DataIC50:  18.4nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50436448(CHEMBL2397186)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using L-a- phosphatidylinositol/OctylGlucoside as substrate after 10 mins by KinaseGlo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380368(CHEMBL2017967)
Affinity DataIC50:  21nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50436448(CHEMBL2397186)
Affinity DataIC50:  22nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using L-a- phosphatidylinositol/OctylGlucoside as substrate after 10 mins by KinaseGlo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380375(CHEMBL2017975)
Affinity DataIC50:  23nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  30nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50:  33nMAssay Description:Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380373(CHEMBL2017972)
Affinity DataIC50:  34nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372471(CHEMBL272265)
Affinity DataIC50:  34nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3K p110deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50436448(CHEMBL2397186)
Affinity DataIC50:  36nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser473 residueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598041(CHEMBL5174001)
Affinity DataIC50:  36nMAssay Description:Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598039(CHEMBL5175657)
Affinity DataIC50:  37nMAssay Description:Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50436448(CHEMBL2397186)
Affinity DataIC50:  39nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser473 residueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598041(CHEMBL5174001)
Affinity DataIC50:  39nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598037(CHEMBL5203121)
Affinity DataIC50:  42nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  44nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using L-alpha-phosphatidylinositol as substrate in presence of ATP by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50:  45nMAssay Description:Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598030(CHEMBL5177354)
Affinity DataIC50:  48nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  52nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  52nMAssay Description:Inhibition of PI3K p110alpha subunit using [gamma33P]ATP by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50:  56nMAssay Description:Inhibition of PI3K p110alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380376(CHEMBL2017976)
Affinity DataIC50:  63nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50372471(CHEMBL272265)
Affinity DataIC50:  64nMAssay Description:Inhibition of PI3K p110alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598037(CHEMBL5203121)
Affinity DataIC50:  65nMAssay Description:Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598030(CHEMBL5177354)
Affinity DataIC50:  65nMAssay Description:Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372471(CHEMBL272265)
Affinity DataIC50:  67nMAssay Description:Inhibition of PI3K p110gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380374(CHEMBL2017973)
Affinity DataIC50:  68nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50:  72nMAssay Description:Inhibition of PI3K p110alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372475(CHEMBL270639)
Affinity DataIC50:  77nMAssay Description:Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598042(CHEMBL5188146)
Affinity DataIC50:  90nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372471(CHEMBL272265)
Affinity DataIC50:  94nMAssay Description:Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598036(CHEMBL5185902)
Affinity DataIC50:  94nMAssay Description:Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50598031(CHEMBL5181013)
Affinity DataIC50:  96nMAssay Description:Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372471(CHEMBL272265)
Affinity DataIC50:  98nMAssay Description:Inhibition of PI3K p110deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 176 total ) | Next | Last >>
Jump to: