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Found 27 with Last Name = 'osier' and Initial = 'm'
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: <100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 3 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at -80 mV resting membrane potential by electrophy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  260nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 1 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  600nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at -120 mV resting membrane potential by electroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  600nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 0.1 Hz frequency by manual patch clamp techniqu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of NaV1.7 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of NaV1.8 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of NaV1.4 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of NaV1.1 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of NaV1.3 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of NaV1.6 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of NaV1.7 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human ERG expressed stably in CHO cells by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of NaV1.2 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173335(CHEBI:87690 | CVT-303 | RS-43285-003 | Ranexa | Ra...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human ERG expressed stably in CHO cells by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of NaV1.4 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of NaV1.3 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.88E+4nMAssay Description:Inhibition of NaV1.8 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of NaV1.6 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of NaV1.2 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  9.60E+4nMAssay Description:Inhibition of NaV1.1 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed