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Found 448 with Last Name = 'laufersweiler' and Initial = 'mc'
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM30359(BOC-piperidinyl glycine derivative, 34)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102477(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102479(4-[Carboxy-(4'-methylsulfanyl-biphenyl-4-sulfonyla...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102477(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102468(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102478(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-(2-me...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102468(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102477(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102474(4-{carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-methy...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102479(4-[Carboxy-(4'-methylsulfanyl-biphenyl-4-sulfonyla...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193734(2-{[3-(4-methoxy-phenyl)-1-(3-trifluoromethyl-benz...)
Affinity DataIC50:  1nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199749(CHEMBL268772 | N-((S,Z)-1-(2-((3S)-2-hydroxy-5-oxo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199766(CHEMBL394351 | N-((S,Z)-1-((S)-1-((3S)-2-hydroxy-5...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102469(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199762(CHEMBL411178 | N-((S,Z)-1-(2-((3S)-2-hydroxy-5-oxo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175348((4S,7S,11aS)-7-(2-naphthamido)-N-((3S)-2-hydroxy-5...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175326((4S,7S,11aS)-N-((3S)-2-hydroxy-5-oxo-tetrahydrofur...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175327((4S,7S,11aS)-N-((3S)-2-hydroxy-5-oxo-tetrahydrofur...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175340((4S,7S,11aS)-7-(2-naphthamido)-N-((3S)-2-hydroxy-5...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175323((4S,7S,11aS)-benzyl 4-(((3S)-2-hydroxy-5-oxo-tetra...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102478(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-(2-me...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102482(4-[carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102476(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175328((4S,7S,11aS)-benzyl 4-(((3S)-2-hydroxy-5-oxo-tetra...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175329((4S,7S,11aS)-N-((3S)-2-hydroxy-5-oxo-tetrahydrofur...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175338((4S,7S,11aS)-7-(benzo[b]thiophene-2-carboxamido)-N...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175337((4S,7S,11aS)-benzyl 4-(((3S)-2-hydroxy-5-oxo-tetra...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175335((4S,7S,11aS)-7-(2-naphthamido)-N-((3S)-2-hydroxy-5...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175347((4S,7S,11aS)-N-((3S)-2-hydroxy-5-oxo-tetrahydrofur...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175346((4S,7S,11aS)-7-(2-naphthamido)-N-((3S)-2-hydroxy-5...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102473((4'-methoxy-biphenyl-4-sulfonylamino)-[1-(morpholi...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102468(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM30359(BOC-piperidinyl glycine derivative, 34)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102476(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102479(4-[Carboxy-(4'-methylsulfanyl-biphenyl-4-sulfonyla...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102473((4'-methoxy-biphenyl-4-sulfonylamino)-[1-(morpholi...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189360((1S,10S)-9-[(Isoquinoline-1-carbonyl)-amino]-6,10-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of caspase-1 using fluorogenic substrate and BMG Fluostar plate reader for 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199763(CHEMBL397184 | N-((S,Z)-6-(benzamidomethyl)-1-(2-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193736(1-(3-(trifluoromethyl)benzyl)-3-(4-methoxyphenyl)-...)
Affinity DataIC50:  2nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175345((4S,7S,11aS)-7-benzamido-N-((3S)-2-hydroxy-5-oxo-t...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199750(CHEMBL243823 | N-((S,Z)-1-(2-((3S)-2-hydroxy-5-oxo...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102474(4-{carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-methy...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102478(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-(2-me...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102482(4-[carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102475(4-[carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50:  2.80nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102473((4'-methoxy-biphenyl-4-sulfonylamino)-[1-(morpholi...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193748(1-(3-(trifluoromethyl)benzyl)-3-(4-methoxyphenyl)-...)
Affinity DataIC50:  3nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50102469(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175342((4S,7S,11aS)-N-((3S)-2-hydroxy-5-oxo-tetrahydrofur...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50369834(CHEMBL402745)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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