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TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615089(CHEMBL5270693)
Affinity DataIC50:  0.00800nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615089(CHEMBL5270693)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50:  0.0250nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  0.0290nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615093(CHEMBL5284924)
Affinity DataIC50:  0.0530nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  0.0590nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615093(CHEMBL5284924)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615094(CHEMBL5285052)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615092(CHEMBL5289859)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615097(CHEMBL5275642)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615094(CHEMBL5285052)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615092(CHEMBL5289859)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615096(CHEMBL5287229)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615090(CHEMBL5280082)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615090(CHEMBL5280082)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615096(CHEMBL5287229)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615089(CHEMBL5270693)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615098(CHEMBL5278657)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615095(CHEMBL5288276)
Affinity DataIC50:  0.860nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615097(CHEMBL5275642)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615097(CHEMBL5275642)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615095(CHEMBL5288276)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615099(CHEMBL5269375)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Technische UniversitÄT Dortmund

LigandPNGBDBM92356(Chir98014, 20)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPutative glycogen synthase kinase 3 alpha(Corn smut fungus)
Technische UniversitÄT Dortmund

LigandPNGBDBM92356(Chir98014, 20)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615098(CHEMBL5278657)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615091(CHEMBL5285308)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615094(CHEMBL5285052)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPutative glycogen synthase kinase 3 alpha(Corn smut fungus)
Technische UniversitÄT Dortmund

LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50:  8nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615093(CHEMBL5284924)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Technische UniversitÄT Dortmund

LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50:  10nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615096(CHEMBL5287229)
Affinity DataIC50:  12nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615092(CHEMBL5289859)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615098(CHEMBL5278657)
Affinity DataIC50:  17nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615090(CHEMBL5280082)
Affinity DataIC50:  19nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615099(CHEMBL5269375)
Affinity DataIC50:  23nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50:  25nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615091(CHEMBL5285308)
Affinity DataIC50:  34nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615097(CHEMBL5275642)
Affinity DataIC50:  35nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPutative glycogen synthase kinase 3 alpha(Corn smut fungus)
Technische UniversitÄT Dortmund

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50:  54nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPutative glycogen synthase kinase 3 alpha(Corn smut fungus)
Technische UniversitÄT Dortmund

LigandPNGBDBM92353(Sorafenib derivative, 16)
Affinity DataIC50:  57nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615099(CHEMBL5269375)
Affinity DataIC50:  73nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50615095(CHEMBL5288276)
Affinity DataIC50:  78nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Technische UniversitÄT Dortmund

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50:  89nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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