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TargetFibroblast growth factor receptor 2(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.30nMAssay Description:Irreversible inhibition of human FGFR2 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.60nMAssay Description:Irreversible inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated with enzyme followed by peptide substrate addition by ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  2.20nMAssay Description:Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  73nMAssay Description:Irreversible inhibition of human FGFR4 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290188(US9572811, Example 84A | US9572811, Example 84B)
Affinity DataIC50:  0.400nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287008(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Affinity DataIC50:  0.400nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197247(US9090621, 84A | US9572811, Example 85A)
Affinity DataIC50:  0.400nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290141(US9572811, Example 27A | US9572811, Example 27B)
Affinity DataIC50:  0.600nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238813(CHEMBL4083740)
Affinity DataIC50:  0.700nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290210(US9572811, Example 139A)
Affinity DataIC50:  0.700nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197225(US9090621, 188 | US9572811, Example 188)
Affinity DataIC50:  0.700nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286381(8-(2-((1-acryloylpiperidin-3-yl)oxy)ethyl)-6-(2,6-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238823(CHEMBL4086567)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238811(CHEMBL4073347)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197262(US9090621, 162A | US9572811, Example 162A)
Affinity DataIC50:  0.900nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290215(US9572811, Example 175B)
Affinity DataIC50:  1nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290201(US9572811, Example 104A)
Affinity DataIC50:  1nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287067(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290132((N-((1r,4r)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyra...)
Affinity DataIC50:  1nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238809(CHEMBL4084708)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287008(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238806(CHEMBL4083151)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197255(US9090621, 105A | US9572811, Example 105B)
Affinity DataIC50:  1.30nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238804(CHEMBL4099578)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238805(CHEMBL4061286)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human FGFR2 preincubated for 15 mins followed by peptide substrate addition measured after 3 hrs by caliper capillary electrophoresis m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287067(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238805(CHEMBL4061286)
Affinity DataIC50:  1.30nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238818(CHEMBL4064081)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM60898(US9090621, 83B | US9572811, Example 83A)
Affinity DataIC50:  1.40nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238818(CHEMBL4064081)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238824(CHEMBL4064756)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197257(US9090621, 106A | US9572811, Example 106B)
Affinity DataIC50:  1.5nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238803(CHEMBL4066763)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290169(US9572811, Example 72A)
Affinity DataIC50:  1.60nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290146(US9572811, Example 32A)
Affinity DataIC50:  1.70nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290143(US9572811, Example 30A)
Affinity DataIC50:  1.70nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290135(US9572811, Example 15A)
Affinity DataIC50:  1.70nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238803(CHEMBL4066763)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286523(8-(2-((1-acryloylpyrrolidin-3-yl)oxy)ethyl)-6-(2,6...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197217(US9090621, 88B | US9572811, Example 43A)
Affinity DataIC50:  1.80nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290140(US9572811, Example 22A | US9572811, Example 22B)
Affinity DataIC50:  1.80nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238821(CHEMBL4088057)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290199(US9572811, Example 102A)
Affinity DataIC50:  2nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290206(US9572811, Example 124A)
Affinity DataIC50:  2nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290144(US9572811, Example 31A)
Affinity DataIC50:  2nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197270(US9090621, 183B | US9572811, Example 182B)
Affinity DataIC50:  2nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197260(US9090621, 125A | US9572811, Example 125)
Affinity DataIC50:  2nMT: 25°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
In DepthDetails US Patent

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