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Found 20 with Last Name = 'kimbrell' and Initial = 'mr'
TargetToll-like receptor 2(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50315416((R)-3-((R)-2-Amino-3-((S)-3-hydroxy-1-methoxy-1-ox...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human TLR2 expressed in HEK-Blue-4 cells assessed as induction of NFkappaB by SEAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Mediquest Therapeutics

Curated by ChEMBL
LigandPNGBDBM50195806(CHEMBL384590 | N-(3-(4-(3-aminopropylamino)butylam...)
Affinity DataIC50:  230nMAssay Description:Inhibition of NFkappaB in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Mediquest Therapeutics

Curated by ChEMBL
LigandPNGBDBM50195808(CHEMBL218163 | N-(3-(4-(3-aminopropylamino)butylam...)
Affinity DataIC50:  310nMAssay Description:Inhibition of NFkappaB in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Mediquest Therapeutics

Curated by ChEMBL
LigandPNGBDBM50195809(CHEMBL218434 | N-(3-(4-(3-aminopropylamino)butylam...)
Affinity DataIC50:  340nMAssay Description:Inhibition of NFkappaB in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 2(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50315417(((R)-3-(2-((R)-2-Amino-3-hydroxypropanamido)ethylt...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human TLR2 expressed in HEK-Blue-4 cells assessed as induction of NFkappaB by SEAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410807(POLUMYXIN B | POLYMIXIN B | POLYMYXIN B)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Mediquest Therapeutics

Curated by ChEMBL
LigandPNGBDBM50195807(CHEMBL218282 | N-(3-(4-(3-aminopropylamino)butylam...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of NFkappaB in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410808(CHEMBL535384)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410816(CHEMBL537642)
Affinity DataIC50:  6.11E+3nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50278696(1-(2-((ethylamino)methyl)-3H-imidazo[4,5-c]quinoli...)
Affinity DataIC50:  7.50E+3nMAssay Description:Antagonist activity at TLR7 (unknown origin) expressed in HEK293 cells by spectrophotometry in presence of 250 ng/mL gardiquimodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410810(CHEMBL537865)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410814(CHEMBL537866)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50278695(1-(4-amino-2-((ethylamino)methyl)-3H-imidazo[4,5-c...)
Affinity DataIC50:  2.50E+4nMAssay Description:Antagonist activity at TLR7 (unknown origin) expressed in HEK293 cells by spectrophotometry in presence of 250 ng/mL gardiquimodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410812(CHEMBL534488)
Affinity DataIC50:  2.76E+4nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410806(CHEMBL538329)
Affinity DataIC50:  3.56E+4nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410815(CHEMBL535159)
Affinity DataIC50:  5.91E+4nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410813(CHEMBL537645)
Affinity DataIC50:  6.14E+4nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410811(CHEMBL534939)
Affinity DataIC50:  1.64E+5nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410809(CHEMBL534490)
Affinity DataIC50:  1.75E+5nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50410817(CHEMBL540367)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed