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Found 2721 with Last Name = 'pan' and Initial = 'n'
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612155(CHEMBL5288797)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612159(CHEMBL5266341)
Affinity DataKi:  0.350nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612156(CHEMBL5288389)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612160(CHEMBL5289467)
Affinity DataKi:  0.470nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
B.V. Patel Pharmaceutical Education and Research Development

Curated by ChEMBL
LigandPNGBDBM50492052(CHEMBL2391834)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612154(CHEMBL5286350)
Affinity DataKi:  0.960nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223986((3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612152(CHEMBL5279810)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612158(CHEMBL5273629)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612166(CHEMBL5284402)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
B.V. Patel Pharmaceutical Education and Research Development

Curated by ChEMBL
LigandPNGBDBM50492052(CHEMBL2391834)
Affinity DataKi:  2.80nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295588(5-chloro-N-((3S,4S)-1-(2-(2-fluoro-4-(2-oxopyridin...)
Affinity DataKi:  3nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612159(CHEMBL5266341)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Oryctolagus cuniculus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324743((3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DIC...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to rabbit factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612155(CHEMBL5288797)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223985(rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimeth...)
Affinity DataKi:  4nM ΔG°:  -47.9kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612160(CHEMBL5289467)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612156(CHEMBL5288389)
Affinity DataKi:  5.10nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50612157(CHEMBL5265873)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to human CA7 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612158(CHEMBL5273629)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295581(4-chloro-N-(1-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-y...)
Affinity DataKi:  6nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295583(4-chloro-N-(1-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-y...)
Affinity DataKi:  6nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  6nMAssay Description:Competitive inhibition of PNP in human DoHH2 cells using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612163(CHEMBL5268744)
Affinity DataKi:  6.10nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
B.V. Patel Pharmaceutical Education and Research Development

Curated by ChEMBL
LigandPNGBDBM50492052(CHEMBL2391834)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  7nMAssay Description:Competitive inhibition of human recombinant PNP using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324771((3R,4R)-N3-(5-chloropyridin-2-yl)-N4-(2-fluoro-4-(...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324757((3R,4R)-N3-(4-chlorophenyl)-1-(N,N-dimethylsulfamo...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295585((R)-4-chloro-N-(1-(2-(2-fluoro-4-(2-oxopyridin-1(2...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612161(CHEMBL5273801)
Affinity DataKi:  8.80nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324755((3R,4R)-N-(4-CHLOROPHENYL)-N'-[2-FLUORO-4-(2-OXOPY...)
Affinity DataKi:  9nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
B.V. Patel Pharmaceutical Education and Research Development

Curated by ChEMBL
LigandPNGBDBM50492052(CHEMBL2391834)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]HEMADO from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of PNP in human MINO cells using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324752((3R,4R)-N3-(4-chlorophenyl)-1-(2,2-difluoroethyl)-...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324754((3R,4R)-1-SULFAMOYL-PYRROLIDINE-3,4-DICARBOXYLIC A...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295587(5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of PNP in human K562 cells using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324758((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of PNP in human Jurkat cells using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of PNP in human PBMC using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295589(5-chloro-N-((3S,4S)-4-ethoxy-1-(2-(2-fluoro-4-(2-o...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of PNP in human MC116 cells using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50382672(CHEMBL2024005)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of PNP in human SU-DHL-1 cells using MSEG as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295584(4-chloro-N-(2-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-y...)
Affinity DataKi:  11nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324767((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  11nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324749((3R,4R)-N3-(4-chlorophenyl)-1-(ethylsulfonyl)-N4-(...)
Affinity DataKi:  11nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
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