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Found 414 with Last Name = 'reddy' and Initial = 'n'
TargetReverse transcriptase(Human immunodeficiency virus 1)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50465693(CHEMBL4283608)
Affinity DataIC50:  0.120nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50465682(CHEMBL4287941)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50465685(CHEMBL4281149)
Affinity DataIC50:  0.380nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50559322(CHEMBL4787382)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559321(CHEMBL4754291)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human KDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human KDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50559323(CHEMBL4794328)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50559327(CHEMBL4787659)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50465690(CHEMBL4282356)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50054792(CHEMBL3341973)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559341(CHEMBL4783353)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50054794(CHEMBL3341971)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559325(CHEMBL4756563)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559338(CHEMBL4752055)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50559330(CHEMBL4778687)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50559324(CHEMBL4782337)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010779(CHEMBL310003 | N-Bicyclo[2.2.1]hept-2-yl-N'-(2-iod...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010779(CHEMBL310003 | N-Bicyclo[2.2.1]hept-2-yl-N'-(2-iod...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559339(CHEMBL4750109)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010759(CHEMBL553896 | N-Adamantan-1-yl-N'-(2-iodo-phenyl)...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010782(CHEMBL553347 | N-Adamantan-2-yl-N'-(2-iodo-phenyl)...)
Affinity DataIC50:  5.20nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559319(CHEMBL4791717)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50559318(CHEMBL4751779)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50137113(CHEMBL3753096)
Affinity DataIC50:  6nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50054793(CHEMBL3341972)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010759(CHEMBL553896 | N-Adamantan-1-yl-N'-(2-iodo-phenyl)...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010742(CHEMBL81773 | N-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010795(CHEMBL81461 | N-Adamantan-2-yl-N'-o-tolyl-guanidin...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50280995(CHEMBL542638 | N-Adamantan-1-yl-N'-o-tolyl-acetami...)
Affinity DataIC50:  6nMAssay Description:The compound was evaluated for binding affinity against sigma opioid receptor using [3H]-DTG radioligand in guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50054793(CHEMBL3341972)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human KDAC1More data for this Ligand-Target Pair
LigandPNGBDBM50559340(CHEMBL4742973)
Affinity DataIC50:  7nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50446953(CHEMBL3115774)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559316(CHEMBL4750646)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010742(CHEMBL81773 | N-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl...)
Affinity DataIC50:  7.70nMAssay Description:In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010764(CHEMBL543597 | N-Adamantan-1-yl-N'-cyclohexyl-guan...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010756(CHEMBL81835 | N-Adamantan-1-yl-N'-o-tolyl-guanidin...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010756(CHEMBL81835 | N-Adamantan-1-yl-N'-o-tolyl-guanidin...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010747(CHEMBL543201 | CHEMBL78777 | N,N'-Bis-(3-ethyl-phe...)
Affinity DataIC50:  8nMAssay Description:Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010747(CHEMBL543201 | CHEMBL78777 | N,N'-Bis-(3-ethyl-phe...)
Affinity DataIC50:  8.30nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50280997(CHEMBL544054 | N-Cyclohexyl-N'-o-tolyl-acetamidine...)
Affinity DataIC50:  9nMAssay Description:The compound was evaluated for binding affinity against sigma opioid receptor using [3H]-DTG radioligand in guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50280994(CHEMBL63508 | N-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl...)
Affinity DataIC50:  9nMAssay Description:The compound was evaluated for binding affinity against sigma opioid receptor using [3H]-DTG radioligand in guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50559333(CHEMBL4755417)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50559325(CHEMBL4756563)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50559326(CHEMBL4749877)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50010768(CHEMBL553535 | N,N'-Di-adamantan-1-yl-guanidine; h...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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