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Found 4676 with Last Name = 'yan' and Initial = 'n'
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334454(CHEMBL1643895 | Ramosetron | US9045501, Ramosetron)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105879(15-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105879(15-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105880(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)
Affinity DataKi:  0.0960nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50014549(CHEMBL3261480 | US9045501, 4)
Affinity DataKi:  0.200nMAssay Description:Displacement of [9-methyl-3H]BRL-43694 from human 5-HT3A receptor after overnight incubation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105879(15-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105893(9-(3-Guanidino-propyl)-15-(3H-imidazol-4-ylmethyl)...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105892(12-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataKi:  0.280nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105889(5-(3-Guanidino-propyl)-8-(1H-indol-3-ylmethyl)-2-n...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105883(3-[25-Acetylamino-4-carbamoyl-13-(3-guanidino-prop...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM93624(5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50014558(ALOSETRON | CHEBI:253342 | Lotronex | US9045501, A...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [9-methyl-3H]BRL-43694 from human 5-HT3A receptor after overnight incubation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50014552(CHEMBL3261483 | US9045501, 8)
Affinity DataKi:  0.5nMAssay Description:Displacement of [9-methyl-3H]BRL-43694 from human 5-HT3A receptor after overnight incubation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105888(6-(3-Guanidino-propyl)-3-(1H-indol-3-ylmethyl)-9-n...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105883(3-[25-Acetylamino-4-carbamoyl-13-(3-guanidino-prop...)
Affinity DataKi:  0.570nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105891(13-Ethyl-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105891(13-Ethyl-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334442((S)-2-methyl-7-(quinuclidin-3-yl)-7,8-dihydropyraz...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334453((S)-5-methyl-2-(quinuclidin-3-yl)-2,3-dihydropyrro...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50014553(CHEMBL3261484)
Affinity DataKi:  0.800nMAssay Description:Displacement of [9-methyl-3H]BRL-43694 from human 5-HT3A receptor after overnight incubation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105894(16-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105895(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)
Affinity DataKi:  0.880nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334452((R)-5-methyl-2-(quinuclidin-3-yl)-2,3-dihydropyrro...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105880(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)
Affinity DataKi:  0.960nMAssay Description:Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM210930(UCP1173)
Affinity DataKi:  1.30nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105887(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM210931(UCP1175)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334445((S)-2-ethyl-7-(quinuclidin-3-yl)-7,8-dihydropyrazo...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105876(15-Amino-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50536185(CHEMBL4588910 | US10870625, Compound 57)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334439((R)-2-methyl-7-(quinuclidin-3-yl)-7,8-dihydropyraz...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334443((R)-4-fluoro-2-methyl-7-(quinuclidin-3-yl)-7,8-dih...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334444((R)-2-ethyl-7-(quinuclidin-3-yl)-7,8-dihydropyrazo...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM210927(UCP1039)
Affinity DataKi:  2.10nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM210929(UCP1172)
Affinity DataKi:  2.10nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105882(CHEMBL2370533 | Cyclo Ac-Cys-Glu-His-D-Phe-(3,4-di...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105882(CHEMBL2370533 | Cyclo Ac-Cys-Glu-His-D-Phe-(3,4-di...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334447((S)-2-isopropyl-7-(quinuclidin-3-yl)-7,8-dihydropy...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334448((S)-2-isobutyl-7-(quinuclidin-3-yl)-7,8-dihydropyr...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50536188(CHEMBL4532935)
Affinity DataKi:  2.5nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105883(3-[25-Acetylamino-4-carbamoyl-13-(3-guanidino-prop...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50536186(CHEMBL4483572)
Affinity DataKi:  2.70nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50429697(CHEMBL2335419)
Affinity DataKi:  2.80nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50014548(CHEMBL3261479 | US9045501, 2)
Affinity DataKi:  3.10nMAssay Description:Displacement of [9-methyl-3H]BRL-43694 from human 5-HT3A receptor after overnight incubation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334446((R)-2-isopropyl-7-(quinuclidin-3-yl)-7,8-dihydropy...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105890(12-Amino-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)
Affinity DataKi:  4nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105880(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105877(12-Acetylamino-6-(3-guanidino-propyl)-3-(1H-indol-...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50334440((R)-7-(quinuclidin-3-yl)-7,8-dihydropyrazolo[3,4,5...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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