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Found 58 with Last Name = 'labrie' and Initial = 'p'
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50060429((R)-2-(4-Fluoro-phenyl)-2-{1-[3-(5-[1,2,4]triazol-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136466(CHEMBL343492 | Dimethyl-[2-(6-pyridin-3-yl-indol-1...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136469(4-[1-(2-Dimethylamino-ethyl)-1H-indol-6-yl]-tetrah...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136462(4-[1-(2-Dimethylamino-ethyl)-1H-indol-6-yl]-tetrah...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136465(CHEMBL343105 | Dimethyl-{2-[6-(tetrahydro-pyran-4-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136471((S)-1-{2-[4-(4-Carbamoyl-phenyl)-piperazin-1-yl]-e...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136464(CHEMBL138873 | Dimethyl-{2-[6-(tetrahydro-thiopyra...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136468(CHEMBL138821 | Dimethyl-[2-(6-thiophen-3-yl-indol-...)
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136467(CHEMBL343712 | {2-[6-(3,6-Dihydro-2H-thiopyran-4-y...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136463(CHEMBL138462 | {2-[6-(3,6-Dihydro-2H-pyran-4-yl)-i...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50136470(CHEMBL139438 | Dimethyl-[2-(6-naphthalen-2-yl-indo...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  97nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  195nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  393nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50:  2.08E+3nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  2.48E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  3.58E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50:  5.82E+3nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  6.68E+3nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50:  7.75E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  1.73E+4nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  2.02E+4nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  2.72E+4nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  4.53E+4nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2A6 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2A6 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2A6 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataEC50:  124nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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