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Found 130 with Last Name = 'messina' and Initial = 'p'
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50031442(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50031442(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  2nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291234(CHEMBL150600 | [(S)-1-((S)-1-Formyl-2-methyl-propy...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291219(CHEMBL151521 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50084655(CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-(...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291225(CHEMBL357595 | {(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50031440(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  6nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182149(4-((4-bromo-1-methyl-1H-indol-3-yl)methylene)-3-(p...)
Affinity DataIC50:  6nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031440(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  6nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291188(((S)-1-{(R)-1-[(S)-1-((S)-1-Formyl-3-methyl-butylc...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291222(CHEMBL423222 | {(S)-1-[(S)-1-(4-Benzyloxy-benzyl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291192(CHEMBL345337 | [(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288611(Alpha-ketocarbonyl boronic ester derivative | CHEM...)
Affinity DataIC50:  8nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291236(CHEMBL356841 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291228(CHEMBL347742 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182139(4-((4-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50:  9nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291194((S)-2-Methanesulfonylamino-4-methyl-pentanoic acid...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182144(4-((5-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50137397(CHEMBL341014 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291218(CHEMBL2371036 | [(S)-1-(1-Formyl-propylcarbamoyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291223(CHEMBL150134 | Naphthalene-2-carboxylic acid {(S)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142287((S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291187(CHEMBL151370 | {(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291226(CHEMBL151829 | [(S)-1-((S)-1-Cyclohexylmethyl-2-ox...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291197(CHEMBL149754 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291205(CHEMBL358404 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291181(CHEMBL150976 | {(S)-2-tert-Butoxy-1-[(R)-1-((R)-1-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291177((S)-2-Acetylamino-4-methyl-pentanoic acid [(R)-1-(...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291207(3-[(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291224(CHEMBL424142 | {(S)-1-[(S)-1-Formyl-2-(3H-imidazol...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291176((S)-2-Acetylamino-4-methyl-pentanoic acid [(R)-1-(...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182141(4-((4-fluoro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50:  17nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182152(4-((5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)meth...)
Affinity DataIC50:  17nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291209(CHEMBL151679 | [(S)-1-{(R)-1-[(S)-1-((S)-1-Formyl-...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291198((R)-2-((S)-2-Acetylamino-propionylamino)-4-methyl-...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291191(CHEMBL151176 | {(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50470197(CHEMBL2114122)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291189(CHEMBL151415 | {(S)-5-Amino-1-[(R)-1-((R)-1-formyl...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288609(Alpha-ketocarbonyl derivative | CHEMBL317337)
Affinity DataIC50:  22nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288609(Alpha-ketocarbonyl derivative | CHEMBL317337)
Affinity DataIC50:  22nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50421409(CHEMBL318779)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182151(4-((5-fluoro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50:  23nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291186((S)-4-Benzyloxycarbonylamino-4-[(R)-1-((R)-1-formy...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182146(4-((4-methoxy-1-methyl-1H-indol-3-yl)methylene)-3-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291229(CHEMBL434278 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182140(4-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-3-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291213(CHEMBL151595 | {(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182142(4-((5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)meth...)
Affinity DataIC50:  32nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291215((S)-2-Acetylamino-4-methyl-pentanoic acid [(R)-1-(...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291195(CHEMBL150076 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
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