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Found 103 with Last Name = 'patel' and Initial = 'pa'
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  170nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  180nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  400nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [A1275T](Human immunodeficiency virus 1 (Virus))
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  890nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase A128T mutant expressed in Escherichia coli BL21(DE3) cells assessed as red...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  910nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as reduction in LED...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [A1275T](Human immunodeficiency virus 1 (Virus))
The Ohio State University

LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  4.61E+3nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataIC50:  2.87E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged LEDGF/p75 binding to recombinant full length N-terminal His-tagged HIV1 integrase expressed in Escherichia coli ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535074(CHEMBL4460215)
Affinity DataIC50:  3.13E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535073(CHEMBL4532605)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535072(CHEMBL4586384)
Affinity DataIC50:  4.41E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535075(CHEMBL4573753)
Affinity DataIC50:  5.91E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535070(CHEMBL4462745)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535071(CHEMBL4513790)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [A1275T](Human immunodeficiency virus 1 (Virus))
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  2.00E+5nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [A1275T](Human immunodeficiency virus 1 (Virus))
The Ohio State University

LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  2.62E+5nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464213(CHEMBL4239768)
Affinity DataEC50:  4.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464214(CHEMBL4249825)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464215(CHEMBL4250799)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464216(CHEMBL4244333)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464217(CHEMBL533658)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464218(CHEMBL4237599)
Affinity DataEC50:  2.19E+4nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464219(CHEMBL4238147)
Affinity DataEC50:  2.70E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464220(CHEMBL4246533)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM70894(2-furfuryl-[2-(m-toluidino)quinazolin-4-yl]amine;h...)
Affinity DataEC50:  1.64E+4nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464221(CHEMBL4248355)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464222(CHEMBL4251375)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464223(CHEMBL4242567)
Affinity DataEC50:  1.63E+4nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464224(CHEMBL4245081)
Affinity DataEC50:  6.40E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464225(CHEMBL4249474)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464226(CHEMBL4248160)
Affinity DataEC50:  2.00E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464227(CHEMBL4243999)
Affinity DataEC50:  6.60E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM71175((2-anilinoquinazolin-4-yl)-(2-furfuryl)amine;hydro...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50464228(CHEMBL4237333)
Affinity DataEC50:  6.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataEC50:  1.61E+4nMAssay Description:Inhibition of recombinant full length HIV1 C-terminal His-tagged integrase multimerization with N-terminal FLAG-tagged integrase expressed in Escheri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of recombinant full length HIV1 C-terminal His-tagged integrase A128T mutant multimerization with N-terminal FLAG-tagged integrase A128T m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280526(CHEMBL4162765)
Affinity DataEC50:  4.40E+3nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280527(CHEMBL4172730)
Affinity DataEC50:  6.10E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280528(CHEMBL4173793)
Affinity DataEC50: >1.00E+5nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280534(CHEMBL4165450)
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280541(CHEMBL4175584)
Affinity DataEC50:  3.10E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280544(CHEMBL4177141)
Affinity DataEC50: >1.00E+5nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280551(CHEMBL4168133)
Affinity DataEC50:  800nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280564(CHEMBL4160484)
Affinity DataEC50:  1.40E+3nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280571(CHEMBL4167406)
Affinity DataEC50:  1.51E+4nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280576(CHEMBL4159076)
Affinity DataEC50: >1.00E+5nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50280577(CHEMBL4165018)
Affinity DataEC50: >1.00E+5nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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