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Found 587 with Last Name = 'mosier' and Initial = 'pd'
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50145015(1-Cyclohexyl-4-[3-((S)-5-methoxy-1,2,3,4-tetrahydr...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membrane without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50064708((R)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine ...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50169599(1-Benzenesulfonyl-3-((R)-1-methyl-pyrrolidin-2-ylm...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50128107(1-[2-(4-Chloro-phenoxy)-1-methyl-ethyl]-4-methyl-p...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membrane without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066282(CHEMBL2417568)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Virginia Commonwealth University

LigandPNGBDBM35928(3-(9,10-dihydroanthracen-9-yl)-N,N-dimethylpropan-...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/moleT: 2°CAssay Description:Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066279(CHEMBL2419121)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [D138N](Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  0.590nM ΔG°:  -52.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066278(CHEMBL2419120)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]diprenorphine from mouse KOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50145012(1-Cyclohexyl-4-[3-((R)-5-methoxy-1,2,3,4-tetrahydr...)
Affinity DataKi:  0.630nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membrane without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066277(CHEMBL2419119)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066280(CHEMBL2419122)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50128110(1-[2-(4-Chloro-phenoxy)-ethyl]-4-methyl-piperidine...)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50585434(CHEMBL5093782)
Affinity DataKi:  0.890nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Mississippi

Curated by ChEMBL
LigandPNGBDBM50370067(CHEMBL1237164)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  0.920nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066344(CHEMBL2419116)
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066276(CHEMBL2419118)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]diprenorphine from mouse KOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to wild type MOR (unknown origin) expressed in CHO cells after 15 mins by Ca2+ mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066284(CHEMBL2419123)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292919(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50585435(CHEMBL5083713)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066276(CHEMBL2419118)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50128108(1-[2-(4-Chloro-phenoxy)-1-methyl-ethyl]-4-methyl-p...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066285(CHEMBL2419124)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50131085(3-Bromo-9-aminomethyl-9,10-dihydroanthracene | C-(...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]diprenorphine from mouse KOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50585436(CHEMBL5080230)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066277(CHEMBL2419119)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]diprenorphine from mouse KOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50169601(1-Benzenesulfonyl-3-((S)-1-methyl-pyrrolidin-2-ylm...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066359(CHEMBL3401558)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50232496(CHEMBL428238 | R-(+)-2-ethyl-5-methoxy-3-[(1-methy...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to wild type MOR (unknown origin) expressed in CHO cells after 15 mins by Ca2+ mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50274042((S)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine ...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066346(CHEMBL2419125)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM34141(CHEMBL76237 | MS-245)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50336564((+)-(R)-1-Cyclohexyl-4-[2-(5-methoxy-1,2,3,4-tetra...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membrane without cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [K227A](Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM214798(Dynorphin A (1-17) | YGGFLRRIRPKLK)
Affinity DataKi:  2.20nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50014997(1-(4-hexyl-2,5-dimethoxyphenyl)propan-2-amine | 2-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor [K227A](Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataKi:  2.5nM ΔG°:  -49.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292919(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to wild type MOR (unknown origin) expressed in CHO cells after 15 mins by Ca2+ mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066278(CHEMBL2419120)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50066358(CHEMBL2419117)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]naloxane from mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Mississippi

Curated by ChEMBL
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membrane without cerebellumMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
Virginia Commonwealth University

LigandPNGBDBM35927(3-(9,10-dihydroanthracen-9-yl)-N-methylpropan-1-am...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/moleT: 2°CAssay Description:Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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