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TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321150(US10174049, Example 17 | US9738658, Example 17 | U...)
Affinity DataIC50:  0.300nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM411440(US10385066, Example 17)
Affinity DataIC50:  0.300nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321150(US10174049, Example 17 | US9738658, Example 17 | U...)
Affinity DataIC50:  0.300nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321150(US10174049, Example 17 | US9738658, Example 17 | U...)
Affinity DataIC50:  0.300nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM351918(4-Amino-6-(1-(3-(trifluoromethoxy)phenyl)-1H-indol...)
Affinity DataIC50:  0.5nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM336120(US9738658, Example 2)
Affinity DataIC50:  0.5nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM411430(US10385066, Example 2)
Affinity DataIC50:  0.5nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321135(US10174049, Example 2)
Affinity DataIC50:  0.5nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50203332(CHEMBL3913908)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510974(5-methyl-1-[4-(1-methyl- 1H-pyrazol-4-yl)phenyl]- ...)
Affinity DataIC50:  0.800nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50287311(CHEMBL4176968)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human DGAT1 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and [3H]-labelled decanoyl-CoA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274165(CHEMBL4126996)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274157(CHEMBL4127656)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510980(1-(2,2-difluoroethyl)-6-(2- hydroxy-2- methylpropo...)
Affinity DataIC50:  1.10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510981(1-(2,2-difluoroethyl)-6-(2- fluoro-2-methylpropoxy...)
Affinity DataIC50:  1.60nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321161(US10174049, Example 28 | US10385066, Example 28 | ...)
Affinity DataIC50:  1.70nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321161(US10174049, Example 28 | US10385066, Example 28 | ...)
Affinity DataIC50:  1.70nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321161(US10174049, Example 28 | US10385066, Example 28 | ...)
Affinity DataIC50:  1.70nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321161(US10174049, Example 28 | US10385066, Example 28 | ...)
Affinity DataIC50:  1.70nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321169(US10174049, Example 36 | US9738658, Example 36 | U...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321145(US10174049, Example 12 | US9738658, Example 12 | U...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321155(US10174049, Example 22 | US10385066, Example 22 | ...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321145(US10174049, Example 12 | US9738658, Example 12 | U...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM336140(US9738658, Example 22)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321169(US10174049, Example 36 | US9738658, Example 36 | U...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321145(US10174049, Example 12 | US9738658, Example 12 | U...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321155(US10174049, Example 22 | US10385066, Example 22 | ...)
Affinity DataIC50:  1.80nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321169(US10174049, Example 36 | US9738658, Example 36 | U...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM411460(US10385066, Example 12)
Affinity DataIC50:  1.80nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM411462(US10385066, Example 36)
Affinity DataIC50:  1.80nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321155(US10174049, Example 22 | US10385066, Example 22 | ...)
Affinity DataIC50:  1.80nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50274156(CHEMBL4128368)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50287453(CHEMBL4163300)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human DGAT1 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and C10-CoA as substrate pretre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50287389(CHEMBL4174767)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human DGAT1 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and C10-CoA as substrate pretre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510905(6-(2-hydroxy-2- methylpropoxy)-N- [(aR)-6-({6- car...)
Affinity DataIC50:  2.20nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510975(1-(difluoromethyl)-5-(4- methanesulfonylphenyl)- N...)
Affinity DataIC50:  2.30nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007606(CHEMBL3238280)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]mibolerone from full length human AR expressed in COS cells after 3.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321166(US10174049, Example 33 | US10385066, Example 33 | ...)
Affinity DataIC50:  2.5nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321166(US10174049, Example 33 | US10385066, Example 33 | ...)
Affinity DataIC50:  2.5nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50287311(CHEMBL4176968)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of recombinant human DGAT1 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and C10-CoA as substrate pretre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321166(US10174049, Example 33 | US10385066, Example 33 | ...)
Affinity DataIC50:  2.5nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321166(US10174049, Example 33 | US10385066, Example 33 | ...)
Affinity DataIC50:  2.5nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510976(5-(4-cyanophenyl)-1- (difluoromethyl)-N-[(4s)- 6-(...)
Affinity DataIC50:  2.70nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321141(US10174049, Example 8 | US10385066, Example 8 | US...)
Affinity DataIC50:  2.90nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM351925(US9796729, 8)
Affinity DataIC50:  2.90nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510968(7-cyclopropyl-6-(2- hydroxy-2- methylpropoxy)-N-[(...)
Affinity DataIC50:  2.90nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321141(US10174049, Example 8 | US10385066, Example 8 | US...)
Affinity DataIC50:  2.90nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321141(US10174049, Example 8 | US10385066, Example 8 | US...)
Affinity DataIC50:  2.90nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50287313(CHEMBL4168991)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human DGAT1 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and C10-CoA as substrate pretre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50287449(CHEMBL4176181)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human DGAT1 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and C10-CoA as substrate pretre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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