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Found 103 with Last Name = 'simon' and Initial = 'rj'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  4nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039664(CHEMBL91890 | N-Biphenyl-4-yl-N-[(carbamoylmethyl-...)
Affinity DataKi:  4nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039665(CHEMBL90649 | CHIR-4531 | N-Benzo[1,3]dioxol-5-ylm...)
Affinity DataKi:  6nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50019056((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039661(CHEMBL327549 | CHIR-4537 | N-({Carbamoylmethyl-[2-...)
Affinity DataKi:  31nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039663(CHEMBL89378 | CHIR-4534 | N-({Carbamoylmethyl-[2-(...)
Affinity DataKi:  46nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50029050((-)-(R)-epinephrine | (-)-3,4-dihydroxy-alpha-((me...)
Affinity DataKi:  4.00E+3nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50029051((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Affinity DataKi:  1.40E+4nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  80nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  80nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111316(8-[4-(3,6-Dioxo-5-{4-[(thiophene-2-carbonyl)-amino...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at CCR2 in human PBMC cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111273(6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2-dihydr...)
Affinity DataIC50:  290nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111298(8-{4-[(7-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111280(1-(4-Chloro-phenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111292(8-{4-[(6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111309(8-{4-[(6-Benzo[b]thiophen-3-yl-4-hydroxy-2-oxo-1,2...)
Affinity DataIC50:  510nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111316(8-[4-(3,6-Dioxo-5-{4-[(thiophene-2-carbonyl)-amino...)
Affinity DataIC50:  510nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111281(8-{4-[(4-Hydroxy-7-naphthalen-2-yl-2-oxo-1,2-dihyd...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111282(8-{4-[(4-Hydroxy-6-naphthalen-2-yl-2-oxo-1,2-dihyd...)
Affinity DataIC50:  670nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111280(1-(4-Chloro-phenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111279(4-Hydroxy-2-oxo-1-p-tolyl-2,5-dihydro-1H-pyrrole-3...)
Affinity DataIC50:  830nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111279(4-Hydroxy-2-oxo-1-p-tolyl-2,5-dihydro-1H-pyrrole-3...)
Affinity DataIC50:  890nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111286(8-{4-[(7-Cyano-4-hydroxy-2-oxo-1,2-dihydro-quinoli...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111309(8-{4-[(6-Benzo[b]thiophen-3-yl-4-hydroxy-2-oxo-1,2...)
Affinity DataIC50:  940nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339630(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-isopropox...)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111273(6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2-dihydr...)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111284(8-{4-[(4-Hydroxy-2-oxo-7-trifluoromethyl-1,2-dihyd...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity at CCR2 in mouse spleen cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339629(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-(trifluor...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339628(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3,4-dichlor...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339627(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophe...)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111299(8-{4-[(4-Hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydro-q...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111319(8-{4-[(4-Hydroxy-2-oxo-6-pentyl-1,2-dihydro-quinol...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111306(8-{4-[(4-Hydroxy-2-oxo-1,2-dihydro-quinoline-3-car...)
Affinity DataIC50:  1.85E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111285(8-(4-(4-hydroxy-2-oxo-1-p-tolyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111313(8-{4-[(6-Chloro-4-hydroxy-2-oxo-1,2-dihydro-quinol...)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111288(8-(4-{[1-(4-Bromo-phenyl)-4-hydroxy-2-oxo-2,5-dihy...)
Affinity DataIC50:  1.99E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111295(8-(4-{[6-(4-Chloro-phenyl)-4-hydroxy-2-oxo-1,2-dih...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111308(8-{4-[(4-Hydroxy-6-iodo-2-oxo-1,2-dihydro-quinolin...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111296(8-(4-{[4-Hydroxy-1-(4-isopropyl-phenyl)-2-oxo-2,5-...)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111314(8-{4-[(6,7-Difluoro-4-hydroxy-2-oxo-1,2-dihydro-qu...)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  2.90E+3nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111303(8-{4-[(5-Chloro-4-hydroxy-2-oxo-1,2-dihydro-quinol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111277(8-{4-[(4-Hydroxy-6-nitro-2-oxo-1,2-dihydro-quinoli...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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