Compile Data Set for Download or QSAR
maximum 50k data
Found 292 with Last Name = 'palte' and Initial = 'rl'
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584324(CHEMBL5088471)
Affinity DataIC50: <0.0800nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609728(CHEMBL5267350)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609742(CHEMBL5286106)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST20-tagged LRRK2 in human SH-SY5Y cells assessed as reduction in pSer935 phosphorylation incubated for 90 mins by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609742(CHEMBL5286106)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of LRRK2 in human PBMCs assessed as reduction in Ser95 phosphorylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609741(CHEMBL5284341)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of GST20-tagged LRRK2 in human SH-SY5Y cells assessed as reduction in pSer935 phosphorylation incubated for 90 mins by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584331(CHEMBL5079796)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584332(CHEMBL5076397)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584330(CHEMBL5070497)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584328(CHEMBL5078277 | US20230303540, Example Ex-1.48)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584325(CHEMBL5085777)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584321(CHEMBL5090739)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584318(CHEMBL5082563)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584316(CHEMBL5070231)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584317(CHEMBL5082260)
Affinity DataIC50: <0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584322(CHEMBL5089102)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609741(CHEMBL5284341)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584326(CHEMBL5094138)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584320(CHEMBL5073571)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609742(CHEMBL5286106)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584329(CHEMBL5089933)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM329724((3S,4R)-1-(1-(2-chloro-6-cyclopropylbenzoyl)-4-flu...)
Affinity DataIC50:  1nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Affinity DataIC50: <1nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST20-tagged LRRK2 in human SH-SY5Y cells assessed as reduction in pSer935 phosphorylation incubated for 90 mins by MSD assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579614(CHEMBL4871970)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584327(CHEMBL5073735)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609738(CHEMBL5267690)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST20-tagged LRRK2 in human SH-SY5Y cells assessed as reduction in pSer935 phosphorylation incubated for 90 mins by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM329726((3S,4R)-1-(1-(2- chloro-6- (trifluoromethyl)benzoy...)
Affinity DataIC50:  2nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609738(CHEMBL5267690)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50577469(CHEMBL4850213)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataIC50:  2nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579610(CHEMBL4873520)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50584319(CHEMBL5085536 | US20230303540, Example Ex-1.24)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50:  3nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50509564(CHEMBL4584679)
Affinity DataIC50:  3nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609729(CHEMBL5290520)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50561035(CHEMBL4763578)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50044164(CHEMBL3314007)
Affinity DataIC50:  3nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579616(CHEMBL4845730)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579611(CHEMBL4871097)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609734(CHEMBL5279615)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50609728(CHEMBL5267350)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST20-tagged LRRK2 in human SH-SY5Y cells assessed as reduction in pSer935 phosphorylation incubated for 90 mins by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50561036(CHEMBL4778978)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50538536(CHEMBL4639893)
Affinity DataIC50:  4nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM256339(US9487490, 1C)
Affinity DataIC50:  4nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579615(CHEMBL4865209)
Affinity DataIC50:  5nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50:  5nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50577476(CHEMBL4852406)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50577471(CHEMBL4864502)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50538548(CHEMBL4640681)
Affinity DataIC50:  5nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 292 total ) | Next | Last >>
Jump to: