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Found 501 with Last Name = 'guler' and Initial = 's'
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356214(CHEMBL1910471)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356215(CHEMBL1910473)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356209(CHEMBL1910466)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356210(CHEMBL1910467)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356208(CHEMBL1910465)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356222(CHEMBL1910648)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356206(CHEMBL1910459)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356218(CHEMBL1910476)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29923(US11066414, Comparative Example 1 | substituted 6-...)
Affinity DataIC50:  1.60nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356216(CHEMBL1910474)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615065(CHEMBL5280227)
Affinity DataIC50:  2nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29910(substituted 6-aminoquinoline-3-carbonitrile, 21)
Affinity DataIC50:  2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21922(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H...)
Affinity DataIC50:  2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356221(CHEMBL1910647)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29922(substituted 6-aminoquinoline-3-carbonitrile, 33)
Affinity DataIC50:  2.20nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615046(CHEMBL5289001)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615031(CHEMBL5281815)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50402023(BI 6727 | VOLASERTIB)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human N-terminal His6-tagged recombinant full-length PLK1 expressed in baculovirus infected Sf9 cells incubated for 15 mins followed by...More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615034(CHEMBL5288130)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356219(CHEMBL1910649)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356220(CHEMBL1910650)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615029(CHEMBL5272346)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615037(CHEMBL5285844)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615032(CHEMBL5268938)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM518537(2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615030(CHEMBL5286243)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29912(substituted 6-aminoquinoline-3-carbonitrile, 23)
Affinity DataIC50:  3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615063(CHEMBL5285363)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615039(CHEMBL5280668)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM518536(2-Allyl-6-((4,4-dimethyl-1,2,3,4-tetrahydroisoquin...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615052(CHEMBL5283530)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356203(CHEMBL1910472)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615051(CHEMBL5285960)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615036(CHEMBL5269559)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615054(CHEMBL5289458)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29909(substituted 6-aminoquinoline-3-carbonitrile, 20)
Affinity DataIC50:  4nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615040(CHEMBL5289015)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615066(CHEMBL5266595)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615050(CHEMBL5274253)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615035(CHEMBL5291431)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615024(CHEMBL5291362)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615038(CHEMBL5267993)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356213(CHEMBL1910470)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615064(CHEMBL5290136)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615025(CHEMBL5269631)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615033(CHEMBL5269511)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615056(CHEMBL5266147)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50615060(CHEMBL5277502)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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