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Found 972 with Last Name = 'pethe' and Initial = 's'
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528106(N-{[5-methoxy-2-(1,2,3,4-tetrazol-1-yl)phenyl]meth...)
Affinity DataKi:  0.100nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528123(N-{[5-chloro-2-(1,2,3,4-tetrazol-1-yl)phenyl]methy...)
Affinity DataKi:  0.160nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM455297(US10730874, Compound TABLE II.2 | US11180484, Exam...)
Affinity DataKi:  0.170nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528127(US11180484, Example 79 | US11180484, Reference Exa...)
Affinity DataKi:  0.230nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528105(N-{[2-fluoro-3-methoxy-6-(1,2,3,4-tetrazol-1-yl)ph...)
Affinity DataKi:  0.260nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528131(1-{[2-(3,3-Difluoropyrrolidin-1-yl)pyrimidin-5-yl]...)
Affinity DataKi:  0.280nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528119(N-{[2-fluoro-3-methoxy-6-(1,2,3,4-tetrazol-1-yl)ph...)
Affinity DataKi:  0.300nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528127(US11180484, Example 79 | US11180484, Reference Exa...)
Affinity DataKi:  0.380nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528074(N-{[2-Fluoro-6-(1,2,3,4-tetrazol-1-yl)phenyl]methy...)
Affinity DataKi:  0.520nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528130(N-{[2-fluoro-3-methoxy-6-(1,2,3,4-tetrazol-1-yl)ph...)
Affinity DataKi:  0.530nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528094(N-[(4-methoxy-3-methylpyridin-2-yl)methyl]-3-(meth...)
Affinity DataKi:  1.90nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528129(N-{[5-methoxy-2-(1,2,3,4-tetrazol-1-yl)phenyl]meth...)
Affinity DataKi:  2.40nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528133(1-{[2-(3,3-difluoropyrrolidin-1-yl)pyrimidin-5-yl]...)
Affinity DataKi:  2.90nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM408717( N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(met...)
Affinity DataKi:  3nMAssay Description:Reversible inhibition of human plasma kallikrein assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM408666(3-Amino-1-[4-(2-oxo-2H-pyridin-1-ylmethyl)-benzyl]...)
Affinity DataKi:  6.70nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528077(N-i6-chloro-2-fluoro-3-methoxybenzyl)-1 -ii2-methy...)
Affinity DataKi:  139nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrypanothione reductase(Trypanosoma brucei brucei)TBA
LigandPNGBDBM50096500(CHEMBL86281 | N,N'-Bis-(3-phenyl-propyl)-N,N'-bis-...)
Affinity DataKi:  600nMAssay Description:Inhibition of Trypanosoma brucei TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Crithidia fasciculata)TBA
LigandPNGBDBM50240622(3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydr...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of Crithidia fasciculata TryR overexpressed in escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615394(CHEMBL5266592)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)TBA
LigandPNGBDBM50096496(CHEMBL62048 | N,N'-Bis-(3-amino-propyl)-N,N'-bis-(...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of Trypanosoma brucei TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50096493(CHEMBL82641 | N,N'-Bis-(3-phenyl-propyl)-N-[3-(3-p...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50408797(CHEMBL151228)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)TBA
LigandPNGBDBM50462235(CHEMBL4244566)
Affinity DataKi:  7.50E+3nMAssay Description:Mixed-type inhibition of Trypanosoma brucei trypanothione reductase assessed as enzyme-inhibitor complex using varying levels of TS2 as substrate in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)TBA
LigandPNGBDBM50096498(CHEMBL86096 | N,N'-Bis-[3-(3-phenyl-propylamino)-p...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of Trypanosoma brucei TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615395(CHEMBL5280891)
Affinity DataKi:  1.59E+4nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)TBA
LigandPNGBDBM50009371(1, 12-DB-3-4-3 | CHEMBL81614 | N,N'-Bis-(3-benzyla...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of Trypanosoma brucei TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)TBA
LigandPNGBDBM50462235(CHEMBL4244566)
Affinity DataKi:  2.00E+4nMAssay Description:Mixed-type inhibition of Trypanosoma brucei trypanothione reductase assessed as enzyme-inhibitor-substrate complex using varying levels of TS2 as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615396(CHEMBL311566)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50096497(CHEMBL85779 | N-(3-Amino-propyl)-N'-[3-(3-phenyl-p...)
Affinity DataKi:  3.70E+4nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Crithidia fasciculata)TBA
LigandPNGBDBM50615384(CHEMBL80264)
Affinity DataKi:  8.50E+4nMAssay Description:Inhibition of Crithidia fasciculata TryR overexpressed in escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615399(CHEMBL82315)
Affinity DataKi:  8.60E+4nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constant by TR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615398(CHEMBL77450)
Affinity DataKi:  9.00E+4nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constant by TR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)TBA
LigandPNGBDBM50615382(CHEMBL211029)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Trypanosoma brucei TryR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50184783(CHEMBL298628 | N*1*-(3-Amino-propyl)-N*1*-naphthal...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50184788((4-Amino-butyl)-(3-amino-propyl)-carbamic acid ben...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615397(CHEMBL210576)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615392(CHEMBL2009956)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constant in presence of NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615391(CHEMBL5277812)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constant in presence of NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615390(CHEMBL210734)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constant in presence of NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)TBA
LigandPNGBDBM50615393(CHEMBL2008816)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of Trypanosoma cruzi TryR assessed as inhibition constant in presence of NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528130(N-{[2-fluoro-3-methoxy-6-(1,2,3,4-tetrazol-1-yl)ph...)
Affinity DataIC50:  0.300nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528122(3-amino-N-{[5-chloro-2-(1,2,3,4-tetrazol-1-yl)phen...)
Affinity DataIC50:  0.300nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528106(N-{[5-methoxy-2-(1,2,3,4-tetrazol-1-yl)phenyl]meth...)
Affinity DataIC50:  0.400nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM50591423(CHEMBL5189653)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-AFC as flurogenic substrate preincubated for 5 mins followed by substrate addition by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528105(N-{[2-fluoro-3-methoxy-6-(1,2,3,4-tetrazol-1-yl)ph...)
Affinity DataIC50:  0.600nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM187100(US9670157, 114 3-Methyl-1-[4-(4-methyl-pyrazol-1-y...)
Affinity DataIC50:  0.600nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM408768(N-[(6-cyano-2-fluoro-3-methoxyphenyl)methyl]-3-(me...)
Affinity DataIC50:  0.600nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM187100(US9670157, 114 3-Methyl-1-[4-(4-methyl-pyrazol-1-y...)
Affinity DataIC50:  0.600nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528108(N-[(6-carbamoyl-2-fluoro-3-methoxyphenyl)methyl]-3...)
Affinity DataIC50:  0.600nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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