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Found 62 with Last Name = 'youssef' and Initial = 's'
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  6.30E+3nMAssay Description:Binding affinity to thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  9.42E+3nMAssay Description:Binding affinity to chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to factor IXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >1.40E+4nMAssay Description:Binding affinity to urokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >1.94E+4nMAssay Description:Binding affinity to plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >2.15E+4nMAssay Description:Binding affinity to activated protein CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >2.20E+4nMAssay Description:Binding affinity to plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >5.50E+4nMAssay Description:Binding affinity to factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26359((2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-N,N...)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26357(3-chloroindole compound, 18 | methyl (2Z)-3-[(3-ch...)
Affinity DataIC50:  8.90nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26360((2Z)-3-[(3-bromo-1H-indol-7-yl)amino]-2-cyano-N,N-...)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26354(2-{[(3-chloro-1H-indol-7-yl)amino]({[(3S)-2-oxo-1-...)
Affinity DataIC50:  9.30nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175078((S,Z)-3-(1-(2-methylbenzofuran-5-ylamino)-3-oxo-3-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175093((S,Z)-2-(4-chlorobenzoyl)-3-(2-methylbenzofuran-5-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175076((S,Z)-2-(4-methoxybenzoyl)-3-(2-methylbenzofuran-5...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175097((S,Z)-1-(2-cyano-3-(2-methylbenzofuran-5-ylamino)-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175095((S,Z)-2-cyano-3-(2-methylbenzofuran-5-ylamino)-3-(...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175079((S,Z)-methyl 2-cyano-3-(2-methylbenzofuran-5-ylami...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175081((S,Z)-ethyl 2-cyano-3-(2-methylbenzofuran-5-ylamin...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26351(2-methylbenzofuran compound, 2 | 2-{[(2-methyl-1-b...)
Affinity DataIC50:  30nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26351(2-methylbenzofuran compound, 2 | 2-{[(2-methyl-1-b...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26364((3S)-1-(3-chloro-1H-indol-7-yl)-2-cyano-2-oxo-1-[2...)
Affinity DataIC50:  46nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175080((S,Z)-3-(2-methylbenzofuran-5-ylamino)-2-(methylsu...)
Affinity DataIC50:  46nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM24777(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175083((S,Z)-3-(1-(2-methylbenzofuran-5-ylamino)-2-nitrov...)
Affinity DataIC50:  51nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175099((S,Z)-3-(2-methylbenzofuran-5-ylamino)-2-(4-methyl...)
Affinity DataIC50:  57nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175084((S,Z)-tert-butyl 2-cyano-3-(2-methylbenzofuran-5-y...)
Affinity DataIC50:  57nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of Aurora A (122 to 403 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in TACC3 phosphoryla...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50594273(CHEMBL181549)
Affinity DataIC50:  90nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26350((S)-1-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)aze...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26350((S)-1-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)aze...)
Affinity DataIC50:  110nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26352(2-{[(3-methyl-1H-indol-7-yl)amino]({[(3S)-2-oxo-1-...)
Affinity DataIC50:  114nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26358((2Z)-2-cyano-N,N-dimethyl-3-[(3-methyl-1H-indol-7-...)
Affinity DataIC50:  118nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50594274(CHEMBL5182750)
Affinity DataIC50:  120nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50594272(CHEMBL5179592)
Affinity DataIC50:  150nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26361((2Z)-2-cyano-3-[(3-cyano-1H-indol-7-yl)amino]-N,N-...)
Affinity DataIC50:  290nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26363((3S)-2-cyano-1-(3-methyl-1H-indol-7-yl)-2-oxo-1-[2...)
Affinity DataIC50:  336nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50594274(CHEMBL5182750)
Affinity DataIC50:  410nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26353(2-[(1H-indol-7-ylamino)({[(3S)-2-oxo-1-[2-oxo-2-(p...)
Affinity DataIC50:  430nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175077((S,Z)-3-(1-(benzofuran-5-ylamino)-2-nitrovinylamin...)
Affinity DataIC50:  539nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM24777(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)
Affinity DataIC50:  620nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175088((S,Z)-2-(isopropylsulfonyl)-3-(2-methylbenzofuran-...)
Affinity DataIC50:  647nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26355(indole-7-yl compound, 16 | methyl (2Z)-2-cyano-3-(...)
Affinity DataIC50:  650nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175082((S,Z)-diethyl 1-cyano-2-(2-methylbenzofuran-5-ylam...)
Affinity DataIC50:  658nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50594273(CHEMBL181549)
Affinity DataIC50:  960nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175086((S,Z)-3-(1-(naphthalen-2-ylamino)-2-nitrovinylamin...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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