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TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300661(3-borono-5-(2-methoxybenzamido)benzoic acid | CHEM...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300664(3-borono-5-(2-phenoxyacetamido)benzoic acid | CHEM...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300662(3-borono-5-(thiophene-2-carboxamido)benzoic acid |...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300660(3-benzamido-5-boronobenzoic acid | CHEMBL575719)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)

Curated by ChEMBL
LigandPNGBDBM50300689(6-chloro-2-(3-(4-chloro-2-methylphenyl)ureido)-3-(...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)

Curated by ChEMBL
LigandPNGBDBM50300688(6-chloro-3-(3,4-dichlorophenoxy)-2-(3-(3-(trifluor...)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300663(3-borono-5-(2-(thiophen-2-yl)acetamido)benzoic aci...)
Affinity DataIC50:  7.80E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300659(3-borono-5-(2-phenylacetamido)benzoic acid | CHEMB...)
Affinity DataIC50:  8.80E+4nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)

Curated by ChEMBL
LigandPNGBDBM50300687(2-(5-((4-chlorophenylthio)methyl)-1,3,4-thiadiazol...)
Affinity DataIC50:  2.19E+5nMAssay Description:Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2X(Streptococcus pneumoniae)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)

Curated by ChEMBL
LigandPNGBDBM50300688(6-chloro-3-(3,4-dichlorophenoxy)-2-(3-(3-(trifluor...)
Affinity DataIC50:  2.55E+5nMAssay Description:Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X preincubated for 1 hr before addition of substrate (R)-[2-(benzoylamino)propiony...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2X(Streptococcus pneumoniae)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)

Curated by ChEMBL
LigandPNGBDBM50300689(6-chloro-2-(3-(4-chloro-2-methylphenyl)ureido)-3-(...)
Affinity DataIC50:  3.36E+5nMAssay Description:Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X preincubated for 1 hr before addition of substrate (R)-[2-(benzoylamino)propiony...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-alanyl-D-alanine carboxypeptidase(Actinomadura sp. (strain R39))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50067893(3-Carboxyphenylboronicacid | 3-boronobenzoic acid ...)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibition of Actinomadura sp. R39 penicillin-binding protein preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2x(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)

Curated by ChEMBL
LigandPNGBDBM50300665(5-boronothiophene-2-carboxylic acid | CHEMBL573906)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate mixture of (R)-[2-(benzoyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPenicillin-binding protein 2X(Streptococcus pneumoniae)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)

Curated by ChEMBL
LigandPNGBDBM50300687(2-(5-((4-chlorophenylthio)methyl)-1,3,4-thiadiazol...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X preincubated for 1 hr before addition of substrate (R)-[2-(benzoylamino)propiony...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed