TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]M-MPEP from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa
Curated by ChEMBL
Chugai Pharma Usa
Curated by ChEMBL
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa
Curated by ChEMBL
Chugai Pharma Usa
Curated by ChEMBL
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.550nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.550nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.810nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.830nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa
Curated by ChEMBL
Chugai Pharma Usa
Curated by ChEMBL
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.860nMAssay Description:Inhibition of human recombinant HDAC10 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as release of AM...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.970nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa
Curated by ChEMBL
Chugai Pharma Usa
Curated by ChEMBL
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant HDAC1 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa
Curated by ChEMBL
Chugai Pharma Usa
Curated by ChEMBL
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa
Curated by ChEMBL
Chugai Pharma Usa
Curated by ChEMBL
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length recombinant human His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system incubated for 1 hr by kinase-g...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.41nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 1.42nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa
Curated by ChEMBL
Chugai Pharma Usa
Curated by ChEMBL
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant HDAC1 (482 residues) by Color-de-Lys assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.79nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair