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Found 147 with Last Name = 'shimada' and Initial = 't'
LigandPNGBDBM50509364(CHEMBL4463968)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509346(CHEMBL4470947)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509358(CHEMBL4534641)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509362(CHEMBL4483030)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146534(CHEMBL100732 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146536(4-(6-Chloro-naphthalene-2-sulfonyl)-1-(5-methyl-4,...)
Affinity DataIC50:  24nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
LigandPNGBDBM50509354(CHEMBL4542665)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509356(CHEMBL4584730)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509360(CHEMBL4538356)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509353(CHEMBL4546647)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50509350(CHEMBL4441993)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509351(CHEMBL4460077)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146535(CHEMBL99483 | [4-(6-Chloro-naphthalene-2-sulfonyl)...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154263(4-(6-Chloro-naphthalene-2-sulfonyl)-1-(5-isopropyl...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154267(4-(6-Chloro-naphthalene-2-sulfonyl)-1-(4,5,6,7-tet...)
Affinity DataIC50:  83nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509355(CHEMBL4551634)
Affinity DataIC50:  89nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50535669(CHEMBL1233930)
Affinity DataIC50:  96nMAssay Description:Inhibition of His-tagged human MTHFD1 ( 1 to 306 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before folitixorin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154264(CHEMBL365654 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  105nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154265(4-(6-Chloro-naphthalene-2-sulfonyl)-1-(5-ethyl-4,5...)
Affinity DataIC50:  110nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50525413(CHEMBL4448117)
Affinity DataIC50:  130nMAssay Description:Inhibition of myostatin (unknown origin) expressed in HEK293 cells incubated for 4 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509359(CHEMBL4474051)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154270(CHEMBL182957 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50585028(CHEMBL5078185)
Affinity DataIC50:  190nMAssay Description:Inhibition of myostatin (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154271(CHEMBL185539 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  190nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509352(CHEMBL4451401)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154266(CHEMBL181749 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  210nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50525413(CHEMBL4448117)
Affinity DataIC50:  260nMAssay Description:Inhibition of myostatin (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154275(CHEMBL183960 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  270nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50254771(CHEMBL4061416)
Affinity DataIC50:  290nMAssay Description:Inhibition of myostatin (unknown origin) expressed in HEK293 cells incubated for 4 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50585029(CHEMBL5092917)
Affinity DataIC50:  300nMAssay Description:Inhibition of myostatin (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50254771(CHEMBL4061416)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells after 4 hrs by dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154273(CHEMBL365826 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  320nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509363(CHEMBL4467997)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509344(CHEMBL4460238)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509347(CHEMBL4526400)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509348(CHEMBL4458187)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509343(CHEMBL4472668)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509342(CHEMBL4438430)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509345(CHEMBL4592118)
Affinity DataIC50:  530nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154262(CHEMBL185141 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  550nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50509364(CHEMBL4463968)
Affinity DataIC50:  570nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154268(CHEMBL363048 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  640nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50535669(CHEMBL1233930)
Affinity DataIC50:  663nMAssay Description:Inhibition of His-tagged human MTHFD2 ( 36 to 350 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before folitixorin and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154272(CHEMBL359966 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  920nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50535650(CHEMBL4540255)
Affinity DataIC50:  940nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50509346(CHEMBL4470947)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50206029(CHEMBL3892004)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells after 4 hrs by dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50154274(CHEMBL184478 | [4-(6-Chloro-naphthalene-2-sulfonyl...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth/differentiation factor 8(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50206029(CHEMBL3892004)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant myostatin expressed in HEK293 cells after 4 hrs by SBE4 based luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50579801(CHEMBL5088992)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CBP (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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