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Found 139 with Last Name = 'carafa' and Initial = 'v'
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50236570(CHEMBL4072206)
Affinity DataKi:  2.18E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50236570(CHEMBL4072206)
Affinity DataKi:  2.22E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  38nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492637(CHEMBL2408696)
Affinity DataIC50:  120nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  130nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492631(CHEMBL2408692)
Affinity DataIC50:  160nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492636(CHEMBL2408694)
Affinity DataIC50:  180nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492634(CHEMBL2408820)
Affinity DataIC50:  180nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492636(CHEMBL2408694)
Affinity DataIC50:  250nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492634(CHEMBL2408820)
Affinity DataIC50:  270nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  310nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492635(CHEMBL2408695)
Affinity DataIC50:  310nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492634(CHEMBL2408820)
Affinity DataIC50:  320nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492633(CHEMBL2408693)
Affinity DataIC50:  340nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492639(CHEMBL2408689)
Affinity DataIC50:  360nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492629(CHEMBL2408819)
Affinity DataIC50:  380nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492637(CHEMBL2408696)
Affinity DataIC50:  400nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492629(CHEMBL2408819)
Affinity DataIC50:  420nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492631(CHEMBL2408692)
Affinity DataIC50:  440nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492633(CHEMBL2408693)
Affinity DataIC50:  460nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492630(CHEMBL2408818)
Affinity DataIC50:  480nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492633(CHEMBL2408693)
Affinity DataIC50:  490nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240935(CHEMBL181459 | N1-(2-(hydroxycarbamoyl)phenyl)-N8-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human recombinant HDAC4 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492637(CHEMBL2408696)
Affinity DataIC50:  550nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50240935(CHEMBL181459 | N1-(2-(hydroxycarbamoyl)phenyl)-N8-...)
Affinity DataIC50:  590nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492630(CHEMBL2408818)
Affinity DataIC50:  600nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492635(CHEMBL2408695)
Affinity DataIC50:  700nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492639(CHEMBL2408689)
Affinity DataIC50:  750nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50302945(CHEMBL584273 | N-hydroxy-4-(((2-(p-tolyloxy)ethyl)...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of human recombinant HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492628(CHEMBL2408821)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244813((E)-N-Hydroxy-3-(5-((E)-3-oxo-3-p-tolylprop-1-enyl...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant HDAC4 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492636(CHEMBL2408694)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50236570(CHEMBL4072206)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492632(CHEMBL2408691)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492638(CHEMBL496108)
Affinity DataIC50:  2.15E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492641(CHEMBL2408688)
Affinity DataIC50:  2.18E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50302946(CHEMBL586040 | N-hydroxy-4-(((2-phenoxyethyl)(5-p-...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human recombinant HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50236566(CHEMBL4088480)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50236564(CHEMBL4104964)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492639(CHEMBL2408689)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492640(CHEMBL2408690)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC1 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50492638(CHEMBL496108)
Affinity DataIC50:  3.35E+3nMAssay Description:Inhibition of full length His-tagged human recombinant HDAC6 expressed in baculovirus system using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50236563(CHEMBL4099169)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50244818((E)-N-Hydroxy-3-(5-((E)-3-(naphthalen-2-yl)-3-oxop...)
Affinity DataIC50:  3.77E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50236568(CHEMBL4103565)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244817((E)-N-Hydroxy-3-(5-((E)-3-(6-methoxynaphthalen-2-y...)
Affinity DataIC50:  4.04E+3nMAssay Description:Inhibition of human recombinant HDAC4 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50244869((E)-3-(5-((E)-3-(2,4-Dichlorophenyl)-3-oxoprop-1-e...)
Affinity DataIC50:  4.29E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244868((E)-3-(5-((E)-3-(2,5-Dichlorophenyl)-3-oxoprop-1-e...)
Affinity DataIC50:  4.31E+3nMAssay Description:Inhibition of human recombinant HDAC4 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244818((E)-N-Hydroxy-3-(5-((E)-3-(naphthalen-2-yl)-3-oxop...)
Affinity DataIC50:  4.38E+3nMAssay Description:Inhibition of human recombinant HDAC4 using Fluor de Lys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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