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Found 441 with Last Name = 'solvibile' and Initial = 'wr'
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309834((S)-1,3'-bipyrrolidin-1'-yl(4-((7-chloro-1H-indol-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309848((R)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309847((S)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309845((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazo...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309837(1,3'-bipyrrolidin-1'-yl(4-((2-phenyl-1H-benzo[d]im...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309851((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-indol-1-yl)meth...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309843((3-(dimethylamino)pyrrolidin-1-yl)(4-((2-methyl-1H...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309834((S)-1,3'-bipyrrolidin-1'-yl(4-((7-chloro-1H-indol-...)
Affinity DataKi:  21.7nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309844(1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazol-1-...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309846((R)-1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazo...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309839((S)-(3-(dimethylamino)pyrrolidin-1-yl)(4-((2-pheny...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309836((3-(ethyl(methyl)amino)pyrrolidin-1-yl)(4-((2-phen...)
Affinity DataKi:  91nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309835((3-(dimethylamino)pyrrolidin-1-yl)(4-((2-phenyl-1H...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309853((S)-1,3'-bipyrrolidin-1'-yl(4-((5-chloro-1H-indol-...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119202(CHEMBL99599 | Nonanoic acid [4-(4-{[2-hydroxy-2-(4...)
Affinity DataKi:  140nMAssay Description:Binding affinity of compound against Beta-2 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309852((S)-1,3'-bipyrrolidin-1'-yl(4-((6-chloro-1H-indol-...)
Affinity DataKi:  150nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119195(CHEMBL317003 | {1-[4-(4-{[(R)-2-Hydroxy-2-(4-hydro...)
Affinity DataKi:  180nMAssay Description:Binding affinity of compound against Beta-2 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309841((3-(dimethylamino)pyrrolidin-1-yl)(4-((2-(pyridin-...)
Affinity DataKi:  235nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119195(CHEMBL317003 | {1-[4-(4-{[(R)-2-Hydroxy-2-(4-hydro...)
Affinity DataKi:  240nMAssay Description:Binding affinity of compound against Beta-1 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309842((4-((1H-benzo[d]imidazol-1-yl)methyl)phenyl)(3-(di...)
Affinity DataKi:  390nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309849(1,3'-bipyrrolidin-1'-yl(3-((1H-benzo[d]imidazol-1-...)
Affinity DataKi:  400nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309840((R)-(3-(dimethylamino)pyrrolidin-1-yl)(4-((2-pheny...)
Affinity DataKi:  440nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309838((3-((2-hydroxyethyl)(methyl)amino)pyrrolidin-1-yl)...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309850(1,3'-bipyrrolidin-1'-yl(2-((1H-benzo[d]imidazol-1-...)
Affinity DataKi:  4.00E+3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119202(CHEMBL99599 | Nonanoic acid [4-(4-{[2-hydroxy-2-(4...)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity of compound against Beta-1 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157485(4-[1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl...)
Affinity DataIC50:  3nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119183(1-[4-(4-{[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-prop...)
Affinity DataIC50:  4nMAssay Description:Compound was tested for the antagonistic activity against Beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157496(4-[1-(2,5-dichlorophenyl)-6-hydroxy-1H-indazol-3-y...)
Affinity DataIC50:  15nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157488(4-(7-chloro-1-cyclopentyl-1H-indazol-3-yl)phenol |...)
Affinity DataIC50:  18nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157483(4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol |...)
Affinity DataIC50:  18nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157501(4-[1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl...)
Affinity DataIC50:  20nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157498(4-(1-butyl-7-chloro-1H-indazol-3-yl)phenol | CHEMB...)
Affinity DataIC50:  25nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119183(1-[4-(4-{[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-prop...)
Affinity DataIC50:  27nMAssay Description:Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157491(4-[1-(2,5-difluorophenyl)-6-hydroxy-1H-indazol-3-y...)
Affinity DataIC50:  31nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157504(4-(7-chloro-1-cyclohexyl-1H-indazol-3-yl)phenol | ...)
Affinity DataIC50:  37nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157489(4-[1-(3-fluorophenyl)-6-hydroxy-1H-indazol-3-yl]be...)
Affinity DataIC50:  39nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157503(4-(7-methyl-1-propyl-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  40nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157500(4-[6-hydroxy-1-(4-methylphenyl)-1H-indazol-3-yl]be...)
Affinity DataIC50:  40nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157486(4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL | CH...)
Affinity DataIC50:  48nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157508(4-[1-(3-chlorophenyl)-6-hydroxy-1H-indazol-3-yl]be...)
Affinity DataIC50:  50nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157502(4-(7-chloro-1-propyl-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  52nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157507(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]-3-...)
Affinity DataIC50:  59nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157487(4-(6-hydroxy-1-propyl-1H-indazol-3-yl)benzene-1,3-...)
Affinity DataIC50:  62nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157493(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]ben...)
Affinity DataIC50:  93nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157505(4-[1-(2-hydroxyethyl)-7-(trifluoromethyl)-1H-indaz...)
Affinity DataIC50:  96nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157484(4-(1-benzyl-7-chloro-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  105nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157493(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]ben...)
Affinity DataIC50:  106nMAssay Description:Displacement of [3H]E2 from ERbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157494(4-(1-butyl-6-hydroxy-1H-indazol-3-yl)benzene-1,3-d...)
Affinity DataIC50:  112nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50220305(4-(3-(2-(amino(3-hydroxypropylamino)methyleneamino...)
Affinity DataIC50:  140nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50220314(CHEMBL237063 | N-(amino(3-hydroxypropylamino)methy...)
Affinity DataIC50:  150nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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